Y
Ying Wei
Researcher at University of California, San Francisco
Publications - 36
Citations - 5633
Ying Wei is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Integrin & Urokinase receptor. The author has an hindex of 28, co-authored 35 publications receiving 5156 citations. Previous affiliations of Ying Wei include Harvard University & Academia Sinica.
Papers
More filters
Journal ArticleDOI
Regulation of Integrin Function by the Urokinase Receptor
Ying Wei,Matvey Lukashev,Daniel I. Simon,Sarah C. Bodary,Steven Rosenberg,Michael Doyle,Harold A. Chapman +6 more
TL;DR: The urokinase-type plasminogen activator receptor (uPAR) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to vitronectin via a ligand binding site on uPAR.
Journal ArticleDOI
Identification of the urokinase receptor as an adhesion receptor for vitronectin.
TL;DR: It is reported that the urokinase receptor (uPAR) is also a high affinity (Kd < 30 nM) receptor for vitronectin, indicating a duality in function for the receptor that intrinsically links matrix adhesion to regulation of protease activity.
Journal ArticleDOI
A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling
TL;DR: It is concluded that ligand-induced signaling necessary for normal β1 integrin function requires caveolin and is regulated by uPAR, and Caveolin and uPAR may operate within adhesion sites to organize kinase-rich lipid domains in proximity to integrins, promoting efficient signal transduction.
Journal ArticleDOI
Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Kevin K. Kim,Ying Wei,Charles Szekeres,Matthias C. Kugler,Paul J. Wolters,Marla L. Hill,James A. Frank,Alexis N. Brumwell,Sarah E. Wheeler,Jordan A. Kreidberg,Harold A. Chapman +10 more
TL;DR: Findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis.
Journal ArticleDOI
Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
Harold A. Chapman,Xiaopeng Li,Jonathan P. Alexander,Alexis N. Brumwell,Walter Lorizio,Kevin Tan,Arnoud Sonnenberg,Ying Wei,Thiennu H. Vu +8 more
TL;DR: The finding that a previously unrecognized subpopulation of mouse alveolar epithelial cells expressing the laminin receptor α6β4, but little or no pro-surfactant C (pro-SPC), is endowed with regenerative potential is reported, supporting the idea that there is a stable AEC progenitor population in the adult lung.