H
Harold A. Chapman
Researcher at University of California, San Francisco
Publications - 194
Citations - 28936
Harold A. Chapman is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cathepsin S & Integrin. The author has an hindex of 87, co-authored 191 publications receiving 26617 citations. Previous affiliations of Harold A. Chapman include University of Utah & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
Kevin K. Kim,Matthias C. Kugler,Paul J. Wolters,Liliane Robillard,Michael G. Galvez,Alexis N. Brumwell,Dean Sheppard,Harold A. Chapman +7 more
TL;DR: Alveolar epithelial cells are revealed as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis.
Journal ArticleDOI
Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency
TL;DR: It is suggested that cathepsin K is a major protease in bone resorption, providing a possible rationale for the treatment of disorders such as osteoporosis and certain forms of arthritis.
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Emerging roles for cysteine proteases in human biology
TL;DR: The ability of macrophages and other cells to mobilize elastolytic cysteine proteases to their surfaces under specialized conditions may also lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis and emphysema.
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Regulation of Integrin Function by the Urokinase Receptor
Ying Wei,Matvey Lukashev,Daniel I. Simon,Sarah C. Bodary,Steven Rosenberg,Michael Doyle,Harold A. Chapman +6 more
TL;DR: The urokinase-type plasminogen activator receptor (uPAR) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to vitronectin via a ligand binding site on uPAR.
Journal ArticleDOI
Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
Brigid L.M. Hogan,Christina E. Barkauskas,Harold A. Chapman,Jonathan A. Epstein,Rajan Jain,Connie C. W. Hsia,Laura E. Niklason,Elizabeth A. Calle,Andrew V. Le,Scott H. Randell,Jason R. Rock,Melinda Snitow,Matthew F. Krummel,Barry R. Stripp,Thiennu H. Vu,Eric S. White,Jeffrey A. Whitsett,Edward E. Morrisey +17 more
TL;DR: The multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair are highlighted.