T
Tsuneo Omura
Researcher at Kyushu University
Publications - 161
Citations - 8792
Tsuneo Omura is an academic researcher from Kyushu University. The author has contributed to research in topics: Cytochrome & Microsome. The author has an hindex of 50, co-authored 161 publications receiving 8627 citations. Previous affiliations of Tsuneo Omura include Nara Medical University.
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Journal ArticleDOI
A New Cytochrome in Liver Microsomes
Tsuneo Omura,Ryo Sato +1 more
TL;DR: This chapter discusses enzymology and its applications in medicine, particularly in the field of regenerative medicine and its role in the treatment of cancer.
Journal ArticleDOI
A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s
TL;DR: Experiments with model sequences containing various nucleotide substitutions established that (C/T)CAAGG(T/C)CA is the strongest binding sequence for Ad4 BP, which strongly suggests that Ad4BP is an indispensable transcription factor for the expression of all the steroidogenic P-450 genes.
Journal ArticleDOI
Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
Shin-ichiro Honda,Ken Ichirou Morohashi,Masatoshi Nomura,Hiroyuki Takeya,Masato Kitajima,Tsuneo Omura +5 more
TL;DR: Comparison of the primary structures of the hormone receptor superfamily showed that Ad4BP was highly homologous to FTZ-F1, which regulates the fushi tarazu gene, and ELP, which is expressed in the murine embryonal carcinoma cells.
Journal ArticleDOI
Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development.
Osamu Hatano,Koichi Takayama,Tsuneo Imai,Michael R. Waterman,Akira Takakusu,Tsuneo Omura,Ken Ichirou Morohashi +6 more
TL;DR: It is suggested that the Müllerian inhibitory substance gene may be a target of Ad4BP since this gene has a conserved Ad4-binding site within the promoter, which is recognized by Ad4 BP expressed in the fetal testes.
Journal ArticleDOI
Forty years of cytochrome P450.
TL;DR: Oxidative metabolism of foreign hydrophobic compounds as the first step of their excretion from the animal body is apparently another major function of cytochrome P450, which protects animals from noxious foreign compounds, man-created and natural.