T
Tyler C. Broussard
Researcher at Louisiana State University
Publications - 6
Citations - 256
Tyler C. Broussard is an academic researcher from Louisiana State University. The author has contributed to research in topics: Pyruvate carboxylase & Biotin carboxyl carrier protein. The author has an hindex of 6, co-authored 6 publications receiving 201 citations. Previous affiliations of Tyler C. Broussard include St. Jude Children's Research Hospital.
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Journal ArticleDOI
Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus
Joshua B. Parsons,Tyler C. Broussard,Jeffrey L. Bose,Jason W. Rosch,Pamela Jackson,Chitra Subramanian,Charles O. Rock +6 more
TL;DR: The function for two conserved gene families and their essential role in the incorporation of host fatty acids by Gram-positive pathogens, and fatty acid kinase to the regulation of virulence factor transcription in S. aureus are revealed.
Journal ArticleDOI
Complex Formation and Regulation of Escherichia coli Acetyl-CoA Carboxylase
TL;DR: Both in vitro and in vivo pull-down assays demonstrated that the three components of E. coli acetyl-CoA carboxylase form a multimeric complex and that complex formation is unaffected by acetyl -CoA, AMPPNP, and mRNA encoding car boxyltransferase.
Journal ArticleDOI
The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase
Tyler C. Broussard,Matthew J. Kobe,Svetlana Pakhomova,David B. Neau,Amanda E. Price,Tyler S. Champion,Grover L. Waldrop +6 more
TL;DR: The crystal structure of E. coli BCCP complexed with BC shows a unique quaternary structure and two distinct interfaces for each BCCP monomer, which provide novel targets for developing antibiotics against bacterial acetyl-CoA carboxylase.
Journal ArticleDOI
Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family
Tyler C. Broussard,Darcie J. Miller,Pamela Jackson,Amanda Nourse,Stephen W. White,Charles O. Rock +5 more
TL;DR: Allelic replacement shows that strains expressing FakB2 mutants are defective in fatty acid incorporation into phospholipids and virulence gene transcription.
Journal ArticleDOI
A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae
Joshua B. Parsons,Matthew W. Frank,Marc J. Eleveld,Joost Schalkwijk,Tyler C. Broussard,Marien I. de Jonge,Charles O. Rock +6 more
TL;DR: This work identifies tesS as the gene responsible for the difference in exogenous fatty acid growth requirement of the ΔplsX strains of S. aureus and S. pneumoniae.