T
Tyler Cannon
Researcher at McGill University
Publications - 4
Citations - 320
Tyler Cannon is an academic researcher from McGill University. The author has contributed to research in topics: Acquired immune system & Parkin. The author has an hindex of 2, co-authored 2 publications receiving 185 citations.
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Journal ArticleDOI
Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1 −/− mice
Diana Matheoud,Tyler Cannon,Aurore Voisin,Anna-Maija Penttinen,Lauriane Ramet,Ahmed M. Fahmy,Charles Ducrot,Annie Laplante,Marie-Josée Bourque,Lei Zhu,Romain Cayrol,Armelle Le Campion,Heidi M. McBride,Samantha Gruenheid,Louis-Eric Trudeau,Michel Desjardins +15 more
TL;DR: Intestinal infection with Gram-negative bacteria in Pink1 −/− mice engages mitochondrial antigen presentation and autoimmune mechanisms that elicit the establishment of cytotoxic mitochondria-specific CD8+ T cells in the periphery and in the brain, supporting the idea that PINK1 is a repressor of the immune system.
Journal ArticleDOI
Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson's disease.
TL;DR: The level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1 −/- mice and isobutyric acid increasing in wild-type mice.
Journal ArticleDOI
Microbes and Parkinson's disease: from associations to mechanisms.
Tyler Cannon,Samantha Gruenheid +1 more
TL;DR: Parkinson's disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors as mentioned in this paper , and the mechanisms leading to PD are still under investigation, with several mechanistic models currently proposed.
Posted ContentDOI
LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation
Ahmed Fahmy,Tyler Cannon,Ali Ahmadi,Yong Zhong Xu,Joel Lanoix,Erwin Schurr,Eric Chevet,Pierre Thibault,Samantha Gruenheid,Heidi M. McBride,Michel Desjardins +10 more
TL;DR: In this article , the authors used a pharmacological and genetic approach to characterize the MitAP pathway at the molecular level, and showed that this antigen presentation pathway is induced in APCs in response to inflammatory signals through the sequential activation of TLR4, cGAS-STING and the Unfolded Protein Response (UPR).