Lei Zhu

TL;DR: Intestinal infection with Gram-negative bacteria in Pink1 −/− mice engages mitochondrial antigen presentation and autoimmune mechanisms that elicit the establishment of cytotoxic mitochondria-specific CD8+ T cells in the periphery and in the brain, supporting the idea that PINK1 is a repressor of the immune system.

TL;DR: It is reported that caspase-12 dampens mucosal immunity to bacterial infection independent of its effects on caspASE-1, and inhibits this mucosal antimicrobial response.

TL;DR: A forward genetic approach is used to identify the R-spondin2 gene (Rspo2) as a major determinant of susceptibility to C. rodentium infection and identify Rspo 2 as a key molecular link between infection and intestinal homeostasis.

TL;DR: The strategy and the analysis of the first 3,377 genomes of Salmonella are presented, which will be used to draw potential links between strains found in fresh produce, humans, animals and the environment.

TL;DR: This study shows that resistance to α‐helical AMPs by the extracellular pathogen C.’rodentium relies primarily on the CroP OM protease, which greatly contributed to the protection of the OM from AMP damage by actively degradingα‐helICAL AMPs before they reach the periplasmic space.