U
Ulf Meyer-Hoffert
Researcher at University of Kiel
Publications - 62
Citations - 4081
Ulf Meyer-Hoffert is an academic researcher from University of Kiel. The author has contributed to research in topics: Proteases & Antimicrobial peptides. The author has an hindex of 33, co-authored 62 publications receiving 3734 citations. Previous affiliations of Ulf Meyer-Hoffert include Karolinska Institutet.
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Journal ArticleDOI
Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia
Jürgen Harder,Ulf Meyer-Hoffert,Luis M. Teran,Lars Schwichtenberg,Joachim Bartels,Steffen Maune,Jens-Michael Schröder +6 more
TL;DR: This work purified antimicrobial activity from supernatants of the A549 lung epithelial cell line, previously stimulated with PA bacteria, by subsequent high performance liquid chromatography and revealed it to be identical with human beta-defensin-2 (hBD-2).
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Secreted enteric antimicrobial activity localises to the mucus surface layer
Ulf Meyer-Hoffert,Mathias W. Hornef,Birgitta Henriques-Normark,Lars-Göran Axelsson,Tore Midtvedt,Katrin Pütsep,Mats Andersson +6 more
TL;DR: Findings show that secreted antimicrobial peptides are retained by the surface-overlaying mucus and thereby provide a combined physical and antibacterial barrier to prevent bacterial attachment and invasion.
Journal ArticleDOI
Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.
Jürgen Harder,Stefanie Dressel,Maike Wittersheim,Jesko Cordes,Ulf Meyer-Hoffert,Ulrich Mrowietz,Regina Fölster-Holst,E. Proksch,Jens-Michael Schröder,Thomas Schwarz,Regine Gläser +10 more
TL;DR: A disturbed skin barrier may trigger AMP induction in AD and psoriasis, and the functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis.
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Differential Gene Induction of Human β-Defensins (hBD-1, -2, -3, and -4) in Keratinocytes Is Inhibited by Retinoic Acid
TL;DR: RA is a potent inhibitor of beta-defensin induction in keratinocytes and might downregulate the inducible innate chemical defense system of human skin.
Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after Superficial
Stefanie Dressel,Maike Wittersheim,Jesko Cordes,Ulf Meyer-Hoffert,Ulrich Mrowietz,E. Proksch,Thomas Schwarz,Regine Gläser +7 more
TL;DR: In this paper, the expression of ribonuclease 7 (RNase 7), psoriasin, and human b-defensins (hBD)-2 and -3 in AD compared with psoriatic and healthy control skin as well as after experimental barrier disruption.