R
Regine Gläser
Researcher at University of Kiel
Publications - 132
Citations - 5625
Regine Gläser is an academic researcher from University of Kiel. The author has contributed to research in topics: Antimicrobial peptides & Medicine. The author has an hindex of 37, co-authored 116 publications receiving 4981 citations.
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Journal ArticleDOI
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
Regine Gläser,Jürgen Harder,Hans Lange,Joachim Bartels,Enno Christophers,Jens-Michael Schröder +5 more
TL;DR: It is shown that keratinocytes secrete, as the main E. coli–killing compound, the S100 protein psoriasin in vitro and in vivo in a site-dependent way, and this protein may be key to the resistance of skin against E coli.
Journal ArticleDOI
Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
Yvonne Dombrowski,Mark Peric,Sarah Koglin,C. Kammerbauer,Christine Göss,David Anz,Maren Simanski,Regine Gläser,Jürgen Harder,Veit Hornung,Richard L. Gallo,Thomas Ruzicka,Robert Besch,Jürgen Schauber +13 more
TL;DR: The authors found that the cathelicidin peptide LL-37, which has antimicrobial function, also served as an anti-inflammatory agent by blocking activation of the DNA-sensing inflammasome, providing new potential targets for the treatment of this chronic skin disease.
Journal ArticleDOI
Dimethylfumarate is a potent inducer of apoptosis in human T cells.
TL;DR: Evidence is provided that the effect of FAE treatment of psoriasis may at least in part be due to induction of apoptosis in activated T cells.
Journal ArticleDOI
Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.
Jürgen Harder,Stefanie Dressel,Maike Wittersheim,Jesko Cordes,Ulf Meyer-Hoffert,Ulrich Mrowietz,Regina Fölster-Holst,E. Proksch,Jens-Michael Schröder,Thomas Schwarz,Regine Gläser +10 more
TL;DR: A disturbed skin barrier may trigger AMP induction in AD and psoriasis, and the functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis.
Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after Superficial
Stefanie Dressel,Maike Wittersheim,Jesko Cordes,Ulf Meyer-Hoffert,Ulrich Mrowietz,E. Proksch,Thomas Schwarz,Regine Gläser +7 more
TL;DR: In this paper, the expression of ribonuclease 7 (RNase 7), psoriasin, and human b-defensins (hBD)-2 and -3 in AD compared with psoriatic and healthy control skin as well as after experimental barrier disruption.