U
Ulrica Sehlstedt
Researcher at Stockholm University
Publications - 7
Citations - 491
Ulrica Sehlstedt is an academic researcher from Stockholm University. The author has contributed to research in topics: Circular dichroism & DNA. The author has an hindex of 7, co-authored 7 publications receiving 482 citations. Previous affiliations of Ulrica Sehlstedt include Chalmers University of Technology.
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Journal ArticleDOI
Interaction of Cationic Porphyrins with DNA
Ulrica Sehlstedt,Seog K. Kim,Pamela Carter,Jerry Goodisman,Jean F. Vollano,Bengt Nordén,James C. Dabrowiak +6 more
TL;DR: A kinetic analysis of the cleavage data revealed that cleavage rates are in the order CoTMPyP > CoTBPyP > coTOPyP with the difference being due to different DNA affinities rather than differences in cleavage rate-constants.
Journal ArticleDOI
Interactions of the antiviral quinoxaline derivative 9-OH-B220 [2, 3-dimethyl-6-(dimethylaminoethyl)- 9-hydroxy-6H-indolo-[2, 3-b]quinoxaline] with duplex and triplex forms of synthetic DNA and RNA.
TL;DR: 9-OH-B220 is found to effectively enhance the thermal stability of both the double and triple helical states of DNA as well as the RNA duplex, and some implications for the applications of this low-toxic, antiviral and easily administered drug in an antigene strategy and its potential use as an antiretroviral agent are discussed.
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Binding mode of porphyrins to poly[d(A-T)(2)] and poly[d(G-C)(2)].
TL;DR: Close analysis of the linear dichroism result reveals that all porphyrins exhibit outside binding when complexed with poly[d(A-T)(2)], regardless of the existence of a central metal and side chain, and demonstrates that an energy transfer from the excited nucleo-bases to porphyrs can occur for metalloporphyrin.
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DNA structural features responsible for sequence-dependent binding geometries of Hoechst 33258.
TL;DR: The importance of the interactions of Hoechst with the exocyclic amino group of guanine and the methyl group of cytosine in determining the binding modes are discussed.
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Effects of minor and major groove-binding drugs and intercalators on the DNA association of minor groove-binding proteins RecA and deoxyribonuclease I detected by flow linear dichroism
TL;DR: Linear dichroism was demonstrated to be an excellent detector of DNA double-strand cleavage by deoxyribonuclease I and each ligand was displaced from its DNA binding site upon completion of RecA association, demonstrating that modification of either groove can affect the properties and behaviour of the other.