Ulrich Unnerstall

TL;DR: This study systematically investigates the role of target-site accessibility, as determined by base-pairing interactions within the mRNA, in microRNA target recognition, and devise a parameter-free model that explains the variability in experiments, predicts validated targets more accurately than existing algorithms, and shows that genomes accommodate site accessibility by preferentially positioning targets in highly accessible regions.

TL;DR: A novel thermodynamic model is described that computes expression patterns as a function of cis-regulatory sequence and of the binding-site preferences and expression of participating transcription factors and is applied to the segmentation gene network of Drosophila melanogaster.

TL;DR: It is demonstrated that injection of 2'O-methyl antisense oligoribonucleotides into early Drosophila embryos leads to specific and efficient depletion of microRNAs and thus permits systematic loss-of-function analysis in vivo.

TL;DR: It is shown that maternal factors consistently act as activators and that gap factors act as repressors, except for the bimodal factor Hunchback, which suggests a simple context-dependent rule for its switch from repressive to activating function.

TL;DR: It is demonstrated that the use of a second genome (D. pseudoobscura) for cross-species comparison significantly improves the prediction accuracy of Stubb, and is a more sensitive approach than intersecting the results of separate runs over the two genomes.