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Ulrike Begley
Researcher at State University of New York System
Publications - 10
Citations - 732
Ulrike Begley is an academic researcher from State University of New York System. The author has contributed to research in topics: DNA damage & Translation (biology). The author has an hindex of 7, co-authored 9 publications receiving 647 citations. Previous affiliations of Ulrike Begley include University at Albany, SUNY.
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Journal ArticleDOI
Trm9-catalyzed tRNA modifications link translation to the DNA damage response.
Ulrike Begley,Madhu Dyavaiah,Ashish Patil,John P. Rooney,Dan DiRenzo,Christine M. Young,Douglas S. Conklin,Richard S. Zitomer,Thomas J. Begley +8 more
TL;DR: It is proposed that Trm9-specific tRNA modifications enhance codon-specific translation elongation and promote increased levels of key damage response proteins.
Journal ArticleDOI
Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival
Dragony Fu,Jennifer A N Brophy,Clement T Y Chan,Kyle Aaquil Atmore,Ulrike Begley,Richard S. Paules,Peter C. Dedon,Thomas J. Begley,Leona D. Samson +8 more
TL;DR: The role of mammalian AlkB proteins beyond that of direct DNA repair is expanded and support a regulatory mechanism in the DNA damage response pathway involving modulation of tRNA modification.
Journal Article
Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival
Dragony Fu,Jennifer A N Brophy,Tsz Yan Clement Chan,Kyle Aaquil Atmore,Peter C. Dedon,Leona D. Samson,Ulrike Begley,Thomas J. Begley,Richard S. Paules +8 more
TL;DR: In this article, human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm5U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival.
Journal ArticleDOI
Two self-splicing group I introns in the ribonucleotide reductase large subunit gene of Staphylococcus aureus phage Twort
TL;DR: Two previously uncharacterized introns, 429 and 1087 nt in length, interrupt the Twort gene coding for the large subunit of ribonucleotide reductase (nrdE), indicating that the introns are removed from the primary transcript in vivo.
Journal ArticleDOI
Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.
John P. Rooney,Ajish George,Ashish Patil,Ulrike Begley,Erin Bessette,Maria R. Zappala,Xin Huang,Douglas S. Conklin,Richard P. Cunningham,Thomas J. Begley +9 more
TL;DR: An ontology mapping approach is developed to identify functional categories over-represented with MMS-toxicity modulating proteins and it is demonstrated that, in addition to DNA re-synthesis (replication, recombination, and repair), proteins involved in mRNA processing and translation influence viability after MMS damage.