Ulrike Bulnheim

TL;DR: The results underline the necessity to take into account the in situ production of growth factors by invading mesenchymal cells in the regenerative niche and raise important questions concerning the exact nature of pro-angiogenic drug- or gene-delivery systems to be incorporated into scaffolds.

TL;DR: Calcium phosphate surfaces are able to drive MSC to osteoblasts in the absence of osteogenic differentiation supplements in the medium and an altered dynamic behaviour of focal adhesions on calcium phosphate surfaces might be involved in the molecular mechanisms which promote osteogenic differentiate.

TL;DR: The results demonstrated a reduced spreading, proliferation as well as phosphorylation of signaling proteins due to the influence of Mn(2+) in a concentration-dependent manner, and it is speculated that the release of manganese when incorporated in a biomaterial surface has to be thoroughly adjusted.

TL;DR: The results implicate that biological functions of MSC can be stimulated by integrin‐mediated mechanical forces and a magnetic field, however, the responses of cells depend strongly on the substrate to which they adhere and on the cross‐talk between integrin-mediated signals and soluble factors.

TL;DR: Topographically modified yttria-stabilized zirconia is a likely material for dental implants with cell stimulating properties achieving or actually exceeding those of titanium.