Journal ArticleDOI
Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials.
Ronald E. Unger,Anne Sartoris,Kirsten Peters,Antonella Motta,Claudio Migliaresi,Martin Kunkel,Ulrike Bulnheim,Joachim Rychly,C. James Kirkpatrick +8 more
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TLDR
The results underline the necessity to take into account the in situ production of growth factors by invading mesenchymal cells in the regenerative niche and raise important questions concerning the exact nature of pro-angiogenic drug- or gene-delivery systems to be incorporated into scaffolds.About:
This article is published in Biomaterials.The article was published on 2007-09-01. It has received 379 citations till now. The article focuses on the topics: Tissue engineering & Bone regeneration.read more
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Scaffold-free vascular tissue engineering using bioprinting.
TL;DR: A fully biological self-assembly approach, which is implemented through a rapid prototyping bioprinting method for scaffold-free small diameter vascular reconstruction and has the ability to engineer vessels of distinct shapes and hierarchical trees that combine tubes of distinct diameters.
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Vascularization in tissue engineering
TL;DR: It is illustrated that combining the efforts of different research lines might be necessary to obtain optimal results in the field of tissue engineering, and the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs are discussed.
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Bioceramics of calcium orthophosphates
TL;DR: Current biomedical applications of calcium orthophosphate bioceramics include replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmentation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery.
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Silk fibroin biomaterials for tissue regenerations.
TL;DR: The present article discusses the processing of silk fibroin into different forms of biomaterials followed by their uses in regeneration of different tissues.
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Vascularization Strategies for Tissue Engineering
TL;DR: This review assesses the current state of the field by outlining the prevailing approaches taken toward producing vascularized tissues and highlighting their strengths and weaknesses.
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Journal ArticleDOI
Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation.
TL;DR: The loss of stringent growth control in transformed osteoblasts and in osteosarcoma cells is accompanied by a deregulation of the tightly coupled relationship between proliferation and progressive expression of genes associated with bone cell differentiation.
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Self-regulation of growth in three dimensions
Judah Folkman,Mark S. Hochberg +1 more
TL;DR: Tumor dormancy resulting from absence of angiogenesis in vivo, may operate by the same mechanism responsible for dormancy of spheroids in vitro, which is proposed to be due to a gradual reduction in the ratio of surface area to volume.
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Angiogenesis and bone repair.
TL;DR: The role of osteogenic factors in the adaptive response and interactive function of OB and EC during the multi-step process of bone repair will be discussed.
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Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A
Martine Deckers,Rutger L. van Bezooijen,Geertje van der Horst,Jakomijn Hoogendam,Chris van der Bent,Socrates E. Papapoulos,Clemens W.G.M. Löwik +6 more
TL;DR: This study investigated whether bone morphogenetic proteins (BMPs) stimulate osteoblastogenesis and angiogenesis through the production of VEGF-A, and used the murine preosteoblast-like cell line KS483, which forms mineralized nodules in vitro.
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Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation.
Martine Deckers,Marcel Karperien,Chris van der Bent,Takeyoshi Yamashita,Socrates E. Papapoulos,Clemens W.G.M. Löwik +5 more
TL;DR: Examination of the expression of VEGF-A, -B, -C, and -D and their receptors in a model of osteoblast differentiation using the mouse preosteoblast-like cell line KS483 found that VEGf-A production during osteOBlast differentiation was stimulated by insulin-like...