U
Umberto Manera
Researcher at University of Turin
Publications - 89
Citations - 1331
Umberto Manera is an academic researcher from University of Turin. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 14, co-authored 54 publications receiving 727 citations. Previous affiliations of Umberto Manera include University of Eastern Piedmont.
Papers
More filters
Journal ArticleDOI
Amyotrophic Lateral Sclerosis Outcome Measures and the Role of Albumin and Creatinine: A Population-Based Study
Adriano Chiò,Andrea Calvo,Giacomo Bovio,Antonio Canosa,Davide Bertuzzo,Francesco Galmozzi,Paolo Cugnasco,Marinella Clerico,Stefania Federica De Mercanti,Enrica Bersano,Stefania Cammarosano,Antonio Ilardi,Umberto Manera,Cristina Moglia,Riccardo Sideri,Kalliopi Marinou,Edo Bottacchi,Fabrizio Pisano,Roberto Cantello,Letizia Mazzini,Gabriele Mora +20 more
TL;DR: Both creatinine and albumin are reliable markers of the severity of clinical status in patients with ALS and can be used in defining prognosis at the time of diagnosis.
Journal ArticleDOI
The multistep hypothesis of ALS revisited: The role of genetic mutations
Adriano Chiò,Letizia Mazzini,Sandra D'Alfonso,Lucia Corrado,Antonio Canosa,Cristina Moglia,Umberto Manera,Enrica Bersano,Maura Brunetti,Marco Barberis,J. H. Veldink,Leonard H. van den Berg,Neil Pearce,William Sproviero,Russell L. McLaughlin,Alice Vajda,Orla Hardiman,James Rooney,Gabriele Mora,Andrea Calvo,Ammar Al-Chalabi +20 more
TL;DR: The identification of a reduced number of steps in patients with ALS with genetic mutations compared to those without mutations supports the idea of ALS as a multistep process and is an important advance for dissecting the pathogenic process in ALS.
Journal ArticleDOI
Cognitive impairment across ALS clinical stages in a population-based cohort.
Adriano Chiò,Cristina Moglia,Antonio Canosa,Umberto Manera,Rosario Vasta,Maura Brunetti,Marco Barberis,Lucia Corrado,Sandra D'Alfonso,Enrica Bersano,Maria Francesca Sarnelli,Valentina Solara,Jean Pierre Zucchetti,Laura Peotta,Barbara Iazzolino,Letizia Mazzini,Gabriele Mora,Andrea Calvo +17 more
TL;DR: The data support the hypothesis that ALS pathology disseminates in a regional ordered sequence, through a cortico-efferent spreading model, and suggest that ALS motor and cognitive components may worsen in parallel, and that cognitive impairment becomes more pronounced when bulbar function is involved.
Journal ArticleDOI
ALS phenotype is influenced by age, sex, and genetics: A population-based study
Adriano Chiò,Cristina Moglia,Antonio Canosa,Umberto Manera,Fabrizio D'Ovidio,Rosario Vasta,Maurizio Grassano,Maura Brunetti,Marco Barberis,Lucia Corrado,Sandra D'Alfonso,Barbara Iazzolino,Laura Peotta,Maria Francesca Sarnelli,Valentina Solara,Jean Pierre Zucchetti,Fabiola De Marchi,Letizia Mazzini,Gabriele Mora,Andrea Calvo +19 more
TL;DR: The data suggest that the spatial–temporal combination of motor and cognitive events leading to the onset and progression of ALS is characterized by a differential susceptibility to the pathologic process of motorand prefrontal cortices and lower motor neurons, and is influenced by age, sex, and gene variants.
Journal ArticleDOI
Secular Trends of Amyotrophic Lateral Sclerosis: The Piemonte and Valle d'Aosta Register.
Adriano Chiò,Gabriele Mora,Cristina Moglia,Umberto Manera,Antonio Canosa,Stefania Cammarosano,Antonio Ilardi,Davide Bertuzzo,Enrica Bersano,Paolo Cugnasco,Maurizio Grassano,Fabrizio Pisano,Letizia Mazzini,Andrea Calvo +13 more
TL;DR: The APC model revealed that the increase of ALS incidence is attributable to a birth cohort effect in women, with a peak in the 1930 cohort, which points to an effect of exogenous factors with a differential effect on the 2 sexes, acting on a genetic background.