Rosario Vasta

TL;DR: The data support the hypothesis that ALS pathology disseminates in a regional ordered sequence, through a cortico-efferent spreading model, and suggest that ALS motor and cognitive components may worsen in parallel, and that cognitive impairment becomes more pronounced when bulbar function is involved.

TL;DR: The data suggest that the spatial–temporal combination of motor and cognitive events leading to the onset and progression of ALS is characterized by a differential susceptibility to the pathologic process of motorand prefrontal cortices and lower motor neurons, and is influenced by age, sex, and gene variants.

TL;DR: In this article, three whole-exome sequencing was performed to identify the disease-associated gene in a case series of unrelated patients diagnosed with juvenile ALS and severe growth retardation, and three de novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient) were identified in 3 unrelated patients and failure to thrive.

TL;DR: The telemedicine experience of an Italian ALS tertiary Center during COVID-19 pandemic could be considered a good complement to face-to-face care, even after social restrictions have been eased.

TL;DR: A Dynamic Bayesian Network model provided the prediction of ALS most probable trajectories over time in terms of important clinical outcomes, including survival and loss of autonomy in functional domains, and provided a tool to stratify patients into subgroups of different prognosis.