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Antonio Canosa
Researcher at University of Turin
Publications - 122
Citations - 2855
Antonio Canosa is an academic researcher from University of Turin. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 25, co-authored 86 publications receiving 1785 citations. Previous affiliations of Antonio Canosa include University of Genoa & National Research Council.
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Journal ArticleDOI
Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy
Anna Montuschi,Barbara Iazzolino,Andrea Calvo,Cristina Moglia,Leonardo Lopiano,Gabriella Restagno,Maura Brunetti,Irene Ossola,Anna Lo Presti,Stefania Cammarosano,Antonio Canosa,Adriano Chiò +11 more
TL;DR: The lower educational attainment in patients with ALS-FTD indicated a possible role of cognitive reserve in ALS-related cognitive impairment, in keeping with a previous Irish study, despite the largely different genetic background of the two populations.
Journal ArticleDOI
Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels.
Fernando Bartolome,Hsiu-Chuan Wu,Victoria S Burchell,Elisavet Preza,Selina Wray,Colin J. Mahoney,Nick C. Fox,Andrea Calvo,Antonio Canosa,Cristina Moglia,Jessica Mandrioli,Adriano Chiò,Richard W. Orrell,Henry Houlden,John Hardy,Andrey Y. Abramov,Helene Plun-Favreau +16 more
TL;DR: Using fibroblasts from patients carrying three independent pathogenic mutations in the VCP gene, it is shown that VCP deficiency causes profound mitochondrial uncoupling leading to decreased mitochondrial membrane potential and increased mitochondrial oxygen consumption.
Journal ArticleDOI
Amyotrophic Lateral Sclerosis Outcome Measures and the Role of Albumin and Creatinine: A Population-Based Study
Adriano Chiò,Andrea Calvo,Giacomo Bovio,Antonio Canosa,Davide Bertuzzo,Francesco Galmozzi,Paolo Cugnasco,Marinella Clerico,Stefania Federica De Mercanti,Enrica Bersano,Stefania Cammarosano,Antonio Ilardi,Umberto Manera,Cristina Moglia,Riccardo Sideri,Kalliopi Marinou,Edo Bottacchi,Fabrizio Pisano,Roberto Cantello,Letizia Mazzini,Gabriele Mora +20 more
TL;DR: Both creatinine and albumin are reliable markers of the severity of clinical status in patients with ALS and can be used in defining prognosis at the time of diagnosis.
Journal ArticleDOI
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Ruth Chia,Marya S. Sabir,Sara Bandres-Ciga,Sara Saez-Atienzar,Regina H. Reynolds,Regina H. Reynolds,Regina H. Reynolds,Emil K. Gustavsson,Emil K. Gustavsson,Ronald L. Walton,Samreen Ahmed,Coralie Viollet,Jinhui Ding,Mary B. Makarious,Monica Diez-Fairen,Makayla K. Portley,Zalak Shah,Yevgeniya Abramzon,Yevgeniya Abramzon,Dena G. Hernandez,Cornelis Blauwendraat,David J. Stone,John D. Eicher,Laura Parkkinen,Olaf Ansorge,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Afina W. Lemstra,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Kevin Morgan,Tammaryn Lashley,Thomas T. Warner,Zane Jaunmuktane,Douglas Galasko,Isabel Santana,Pentti J. Tienari,Liisa Myllykangas,Minna Oinas,Nigel J. Cairns,John C. Morris,Glenda M. Halliday,Vivianna M. Van Deerlin,John Q. Trojanowski,Maurizio Grassano,Maurizio Grassano,Andrea Calvo,Gabriele Mora,Antonio Canosa,Gianluca Floris,Ryan C. Bohannan,Francesca Brett,Ziv Gan-Or,Joshua T. Geiger,Anni Moore,Patrick May,Rejko Krüger,Rejko Krüger,David S. Goldstein,Grisel Lopez,Nahid Tayebi,Ellen Sidransky,Lucy Norcliffe-Kaufmann,Jose-Alberto Palma,Horacio Kaufmann,Vikram G. Shakkottai,Matthew H. Perkins,Kathy L. Newell,Thomas Gasser,Claudia Schulte,Francesco Landi,Erika Salvi,Daniele Cusi,Eliezer Masliah,Ronald C. Kim,Chad A. Caraway,Edwin S. Monuki,Maura Brunetti,Ted M. Dawson,Liana S. Rosenthal,Marilyn S. Albert,Olga Pletnikova,Juan C. Troncoso,Margaret E. Flanagan,Qinwen Mao,Eileen H. Bigio,Eloy Rodríguez-Rodríguez,Jon Infante,Carmen Lage,Isabel González-Aramburu,Pascual Sánchez-Juan,Bernardino Ghetti,Julia Keith,Sandra E. Black,Mario Masellis,Ekaterina Rogaeva,Charles Duyckaerts,Alexis Brice,Suzanne Lesage,Georgia Xiromerisiou,Matthew J. Barrett,Bension S. Tilley,Steve M. Gentleman,Giancarlo Logroscino,Geidy E. Serrano,Thomas G. Beach,Ian G. McKeith,Alan J. Thomas,Johannes Attems,Christopher Morris,Laura Palmer,Seth Love,Claire Troakes,Safa Al-Sarraj,Angela Hodges,Dag Aarsland,Dag Aarsland,Gregory Klein,Scott M. Kaiser,Randy Woltjer,Pau Pastor,Lynn M. Bekris,James B. Leverenz,Lilah M. Besser,Amanda B. Kuzma,Alan E. Renton,Alison Goate,David A. Bennett,Clemens R. Scherzer,Huw R. Morris,Raffaele Ferrari,Diego Albani,Stuart Pickering-Brown,Kelley Faber,Walter A. Kukull,Estrella Morenas-Rodríguez,Estrella Morenas-Rodríguez,Alberto Lleó,Juan Fortea,Daniel Alcolea,Jordi Clarimón,Mike A. Nalls,Luigi Ferrucci,Susan M. Resnick,Toshiko Tanaka,Tatiana Foroud,Neill R. Graff-Radford,Zbigniew K. Wszolek,Tanis J. Ferman,Bradley F. Boeve,John Hardy,Eric J. Topol,Ali Torkamani,Andrew B. Singleton,Mina Ryten,Mina Ryten,Dennis W. Dickson,Adriano Chiò,Owen A. Ross,J. Raphael Gibbs,Clifton L. Dalgard,Bryan J. Traynor,Bryan J. Traynor,Bryan J. Traynor,Sonja W. Scholz +166 more
TL;DR: This article performed whole-genome sequencing in large cohorts of Lewy body dementia (LBD) cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community.
Journal ArticleDOI
The multistep hypothesis of ALS revisited: The role of genetic mutations
Adriano Chiò,Letizia Mazzini,Sandra D'Alfonso,Lucia Corrado,Antonio Canosa,Cristina Moglia,Umberto Manera,Enrica Bersano,Maura Brunetti,Marco Barberis,J. H. Veldink,Leonard H. van den Berg,Neil Pearce,William Sproviero,Russell L. McLaughlin,Alice Vajda,Orla Hardiman,James Rooney,Gabriele Mora,Andrea Calvo,Ammar Al-Chalabi +20 more
TL;DR: The identification of a reduced number of steps in patients with ALS with genetic mutations compared to those without mutations supports the idea of ALS as a multistep process and is an important advance for dissecting the pathogenic process in ALS.