* Starting from Need* Evolution of the Toyota Production System* Further Development* Genealogy of the Toyota Production System* The True Intention of the Ford System* Surviving the Low-Growth Period

Toyota production system : beyond large-scale production

Micromachining technology was used to prepare chemical analysis systems on glass chips (1 centimeter by 2 centimeters or larger) that utilize electroosmotic pumping to drive fluid flow and electrophoretic separation to distinguish sample components. Capillaries 1 to 10 centimeters long etched in the glass (cross section, 10 micrometers by 30 micrometers) allow for capillary electrophoresis-based separations of amino acids with up to 75,000 theoretical plates in about 15 seconds, and separations of about 600 plates can be effected within 4 seconds. Sample treatment steps within a manifold of intersecting capillaries were demonstrated for a simple sample dilution process. Manipulation of the applied voltages controlled the directions of fluid flow within the manifold. The principles demonstrated in this study can be used to develop a miniaturized system for sample handling and separation with no moving parts.

Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip

Introduction A Why POC Diagnostics? B Time B Patient Responsibility and Compliance B Cost B Diagnostic Targets C Proteins C Metabolites and Other Small Molecules C Nucleic Acids C Human Cells D Microbes/Pathogens D Drugs and Food Safety D Current Context of POC Assays E POC Glucose Assays E Lateral Flow Assays E Limitations of “Traditional” POC Approaches F Enabling Technologies G Printing and Laminating G Microfluidic Technologies and Approaches: “Unit Operations” for POC Devices G Pumping and Valving H Mixing I Separation I Reagent Storage J Sample Preparation K Surface Chemistry and Device Substrates L Physical Adsorption L Bioaffinity Attachment L Covalent Attachment M Substrate Materials M Detection M Electrochemical Detection N Optical Detection N Magnetic Detection N Label-Free Methods O Enabling Multiplexed Assays O Recent Innovation O Lateral Flow Assay Technologies O Proteins P Antibodies P Protein Expression and Purification Q Nucleic Acids Q Aptamers R Infectious Diseases and Food/Water Safety R Blood Chemistry S Coagulation Markers S Whole Cells S Trends, Unmet Needs, Perspectives T Glucose T Global Health and the Developing World T Personalized Medicine and Home Testing U Technology Trends U Multiplexing V Author Information V Biographies V Acknowledgment W References W

/pdf/point-of-care-diagnostics-status-and-future-5c7xkio6mh.pdf

Point of care diagnostics: Status and future

This tutorial review offers protocols, tips, insight, and considerations for practitioners interested in using micromilling to create microfluidic devices. The objective is to provide a potential user with information to guide them on whether micromilling would fill a specific need within their overall fabrication strategy. Comparisons are made between micromilling and other common fabrication methods for plastics in terms of technical capabilities and cost. The main discussion focuses on “how-to” aspects of micromilling, to enable a user to select proper equipment and tools, and obtain usable microfluidic parts with minimal start-up time and effort. The supplementary information provides more extensive discussion on CNC mill setup, alignment, and programming. We aim to reach an audience with minimal prior experience in milling, but with strong interests in fabrication of microfluidic devices.

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Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices

Proceedings of SPIE - The International Society for Optical Engineering

Microfluidic devices have several applications in different fields, such as chemistry, medicine and biotechnology. Many research activities are currently investigating the manufacturing of integrated microfluidic devices on a mass-production scale with relatively low costs. This is especially important for applications where disposable devices are used for medical analysis. Micromoulding of thermoplastic polymers is a developing process with great potential for producing low-cost microfluidic devices. Among different micromoulding techniques, micro-injection moulding is one of the most promising processes suitable for manufacturing polymeric disposable microfluidic devices. This review paper aims at presenting the main significant developments that have been achieved in different aspects of micro-injection moulding of microfluidic devices. Aspects covered include device design, machine capabilities, mould manufacturing, material selection and process parameters. Problems, challenges and potential areas for research are highlighted.

/pdf/micro-injection-moulding-of-polymer-microfluidic-devices-20vjp0t127.pdf

Micro-injection moulding of polymer microfluidic devices

Micro-powder injection moulding (µPIM) is a fast-developing micro-manufacturing technique for the production of metal and ceramic components. Shape complexity, dimensional accuracy, replication fidelity, material variety combined with high-volume capabilities are some of the key advantages of the technology. This review assesses the capabilities and limitations of µPIM as a micro-manufacturing technique by reviewing the latest developments in the area and by considering potential improvements. The basic elements of the process chain, variant processes and simulation attempts are discussed and evaluated. Challenges and research gaps are highlighted, and potential areas for improvement are presented.

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A review of micro-powder injection moulding as a microfabrication technique

This article presents a transformation process towards lean product development in an aerospace industry. This transformation was achieved in two main stages: the first was to integrate the principles of set-based concurrent engineering into an existing product development model of an aerospace company. This stage included defining activities and associated tools. The second stage was to implement the developed model in a research-based industrial case study, a helicopter engine in this case. Three main outcomes were realised from this work. First, it presented an industrial case of lean transformation in product development, where the leanness of an existing model was enhanced by embedding set-based concurrent engineering principles. Second, the developed model was structured into a set of well-defined activities and associated tools that were previously scattered or redundant. Finally, the developed model was trialled in an industrial project of a helicopter engine, tested to evaluate its value in enhan...

The transformation of product development process into lean environment using set-based concurrent engineering: A case study from an aerospace industry:

This paper addresses the use of micro-injection moulding for the fabrication of polymeric parts with microfeatures. Five separate parts with different micro-feature designs are moulded of Polymethylmethacrylate. The design-of-experiments approach is applied to correlate the quality of the parts to the processing parameters. Five processing parameters are investigated using a screening half-factorial experimentation plan to determine their possible effect on the filling quality of the moulded parts. The part mass is used as an output parameter to reflect the filling of the parts. The experiments showed that the holding pressure is the most significant processing parameter for all the different shapes. In addition, the experiments showed that the geometry of the parts plays a role in determining the significant processing parameters. For a more complex part, injection speed and mould temperature became statistically significant. A desirability function approach was successfully used to improve the filling quality of each part.

/pdf/an-evaluation-of-process-parameter-and-part-geometry-effects-16md8lkt2r.pdf

An evaluation of process-parameter and part-geometry effects on the quality of filling in micro-injection moulding

This paper presents a statistical technique to optimise process conditions for multiple quality criteria in micro-injection moulding. A sample hierarchical component with micro-features was replicated where it was required to improve the process conditions for both complete mould filling and variability in mass. A design-of-experiments approach was used to investigate the effect of five processing parameters on both criteria. It was found that holding pressure, melt temperature and injection velocity were statistically significant for part mass, whereas injection velocity alone was significant for mass variation. Desirability functions were used to predict processing conditions that improved both requirements within pre-set conditions. The technique was validated by experiment and it was shown to be applicable for process parameters for multiple criteria.

/pdf/optimising-process-conditions-for-multiple-quality-criteria-2jercukvjg.pdf

Usama M. Attia

Papers

Micro-injection moulding of polymer microfluidic devices

A review of micro-powder injection moulding as a microfabrication technique

The transformation of product development process into lean environment using set-based concurrent engineering: A case study from an aerospace industry:

An evaluation of process-parameter and part-geometry effects on the quality of filling in micro-injection moulding

Optimising process conditions for multiple quality criteria in micro-injection moulding