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Utham K. Valekunja
Researcher at University of Pennsylvania
Publications - 15
Citations - 1277
Utham K. Valekunja is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: CLOCK & Circadian clock. The author has an hindex of 9, co-authored 14 publications receiving 1039 citations. Previous affiliations of Utham K. Valekunja include National Institute for Health Research & University of Cambridge.
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Journal ArticleDOI
Peroxiredoxins are conserved markers of circadian rhythms
Rachel S. Edgar,Edward W. Green,Yuwei Zhao,Gerben van Ooijen,María Teresa Camacho Olmedo,Ximing Qin,Yao Xu,Min Pan,Utham K. Valekunja,Kevin A. Feeney,Elizabeth S. Maywood,Michael H. Hastings,Nitin S. Baliga,Martha Merrow,Andrew J. Millar,Carl Hirschie Johnson,Charalambos P. Kyriacou,John S. O’Neill,Akhilesh B. Reddy +18 more
TL;DR: It is shown that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms and exploring the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system.
Journal ArticleDOI
Circadian rhythms in the absence of the clock gene Bmal1
Sandipan Ray,Utham K. Valekunja,Alessandra Stangherlin,Steven Howell,Ambrosius P. Snijders,Gopinath Damodaran,Akhilesh B. Reddy +6 more
TL;DR: Unexpectedly, in Bmal1 knockout mice, both tissues exhibited 24-hour oscillations of the transcriptome, proteome, and phosphoproteome over 2 to 3 days in the absence of any exogenous drivers such as daily light or temperature cycles, suggesting that such oscillations might be underpinned by transcriptional regulation by the recruitment of ETS family transcription factors, and nontranscriptionally by co-opting redox oscillations.
Journal ArticleDOI
The Pentose Phosphate Pathway Regulates the Circadian Clock
Guillaume Rey,Utham K. Valekunja,Kevin A. Feeney,Lisa Wulund,Nikolay B. Milev,Alessandra Stangherlin,Laura Ansel-Bollepalli,Vidya Velagapudi,John S. O’Neill,Akhilesh B. Reddy +9 more
TL;DR: The pentose phosphate pathway (PPP), a critical source of the redox cofactor NADPH, is identified as an important regulator of redox and transcriptional oscillations, suggesting a pivotal role for NADPH availability in circadian timekeeping.
Journal ArticleDOI
Histone methyltransferase MLL3 contributes to genome-scale circadian transcription
Utham K. Valekunja,Rachel S. Edgar,Malgorzata Oklejewicz,Gijsbertus T. J. van der Horst,John S. O’Neill,Filippo Tamanini,Daniel J. Turner,Akhilesh B. Reddy +7 more
TL;DR: Circadian modification of an activating histone mark at a significant proportion of gene loci that undergo daily transcription is demonstrated, implicating widespread epigenetic modification as a key node regulated by the clockwork.
Journal ArticleDOI
Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans
María Teresa Camacho Olmedo,John S. O’Neill,Rachel S. Edgar,Utham K. Valekunja,Akhilesh B. Reddy,Martha Merrow +5 more
TL;DR: This work applied low-amplitude temperature cycles to synchronize populations of animals through development and reveals rhythms on multiple levels: in olfactory cued behavior, in RNA and protein abundance, and in the oxidation state of a broadly conserved peroxiredoxin protein.