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Utsa Karmakar
Researcher at University of Edinburgh
Publications - 8
Citations - 129
Utsa Karmakar is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Chemokine & Medicine. The author has an hindex of 2, co-authored 5 publications receiving 34 citations.
Papers
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Journal ArticleDOI
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Nikhil Hirani,Alison C. MacKinnon,Lisa Nicol,Paul Ford,Hans Thalsgaard Schambye,Anders Pedersen,Ulf J. Nilsson,Hakon Leffler,Tariq Sethi,Susan Tantawi,Lise Gravelle,Robert J. Slack,Ross Mills,Utsa Karmakar,Duncan Humphries,Fredrik Zetterberg,Lucy Keeling,Lyn Paul,Philip L. Molyneaux,Feng Li,Wendy Funston,Ian Forrest,A. John Simpson,A. John Simpson,Michael A Gibbons,Toby M. Maher,Toby M. Maher +26 more
TL;DR: In this phase 1/2a clinical study, inhaled TD139 was safe, well tolerated, and demonstrated target engagement and decreased plasma biomarkers associated with IPF progression.
Journal ArticleDOI
Crosstalk between B cells and neutrophils in rheumatoid arthritis.
Utsa Karmakar,Sonja Vermeren +1 more
TL;DR: A review of the central function of citrullination, a post-translational modification of arginine residues in rheumatoid arthritis, is presented in this paper.
Journal ArticleDOI
Immune complex-induced neutrophil functions: A focus on cell death.
TL;DR: The interesting observations and consequences that immune complexes have on neutrophil cell death processes such as apoptosis are discussed.
Journal ArticleDOI
Enzyme‐Activatable Chemokine Conjugates for In Vivo Targeting of Tumor‐Associated Macrophages
Nicole D. Barth,Floris J. van Dalen,Utsa Karmakar,Marco Bertolini,Lorena Mendive-Tapia,Takanori Kitamura,Martijn Verdoes,Marc Vendrell +7 more
TL;DR: The first enzyme-activatable chemokine conjugates for effective targeting of defined macrophage subsets in live tumors are reported, opening new avenues in the design of targeted theranostic probes for immune cells in the tumor microenvironment.
Journal ArticleDOI
Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions.
Utsa Karmakar,Julia Y. Chu,Kruthika Sundaram,Anne Astier,Anne Astier,Hannah Garside,Carsten G. Hansen,Ian Dransfield,Sonja Vermeren +8 more
TL;DR: In this article, the authors demonstrate that iICs trigger FcγRIIa-dependent neutrophil macropinocytosis, leading to the rapid uptake, and subsequent degradation of IICs.