V
Vaclav Liska
Researcher at Charles University in Prague
Publications - 166
Citations - 2522
Vaclav Liska is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Colorectal cancer & Medicine. The author has an hindex of 20, co-authored 130 publications receiving 1922 citations. Previous affiliations of Vaclav Liska include Academy of Sciences of the Czech Republic & University of West Bohemia.
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Journal ArticleDOI
Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome
Lorna Flanagan,Jasmin Schmid,Matthias P. Ebert,Pavel Soucek,Tereza Kunická,Vaclav Liska,Jan Bruha,Paul Neary,Nicki Dezeeuw,Massimo Tommasino,Mazda Jenab,Jochen H. M. Prehn,David J. Hughes +12 more
TL;DR: This is the first study examining Fusobacterium nucleatum (Fn) in the colonic tissue and stool of European CRC and CRA patients, and suggests Fn as a novel risk factor for disease progression from adenoma to cancer, possibly affecting patient survival outcomes.
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HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients.
Miroslav Svoboda,Jana Slyskova,Michaela Schneiderova,Peter J. Makovicky,Ludovit Bielik,Miroslav Levy,Ludmila Lipska,Beáta Hemmelová,Zdenek Kala,Markéta Protivánková,Ondrej Vycital,Vaclav Liska,Lucie Schwarzova,Ludmila Vodickova,Pavel Vodicka +14 more
TL;DR: Analysis of HOTAIR expression levels in tumor and blood of incident sporadic CRC patients in relation to their overall survival and mortality suggests that HOTA IR blood levels may serve as potential surrogate prognostic marker in sporadic CRC.
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The role of ABC transporters in progression and clinical outcome of colorectal cancer.
Ivona Hlavata,Beatrice Mohelnikova-Duchonova,Radka Vaclavikova,Vaclav Liska,Pavel Pitule,Novák P,Jan Bruha,O. Vycital,Lubos Holubec,Vladislav Treska,Pavel Vodicka,Pavel Soucek +11 more
TL;DR: In this paper, the authors explored transcript levels of all known human ATP-binding cassette transporters in colorectal cancer (CRC) patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen.
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Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases.
Vlastimil Kulda,Martin Pesta,Ondrej Topolcan,Vaclav Liska,Vladislav Treska,Sutnar A,Rupert K,Marie Ludvíková,Vaclav Babuska,Lubos Holubec,Radim Cerny +10 more
TL;DR: The hypothesis about oncogenic function of miR-21 is supported and its relation to disease-free interval (DFI) is shown to be more complex than previously thought, suggesting that the role ofmiR-143 in carcinogenesis seems to beMore complex.
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Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas.
Jana Slyskova,Vlasta Korenkova,Andrew Collins,Pavel Prochazka,Ludmila Vodickova,Jiri Svec,Ludmila Lipska,Miroslav Levy,Michaela Schneiderova,Vaclav Liska,Lubos Holubec,Rajesh Kumar,Pavel Soucek,Alessio Naccarati,Pavel Vodicka +14 more
TL;DR: The feasibility of DRC evaluation in human solid tissues is shown, representing a complex marker of multigene DNA repair processes, and it is shown that tumor cells are not deficient in BER and NER, but rather follow patterns characteristic for each individual and are comparable with adjacent tissue.