J
Jana Slyskova
Researcher at Academy of Sciences of the Czech Republic
Publications - 30
Citations - 1283
Jana Slyskova is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: DNA repair & Nucleotide excision repair. The author has an hindex of 17, co-authored 28 publications receiving 1159 citations. Previous affiliations of Jana Slyskova include First Faculty of Medicine, Charles University in Prague & Charles University in Prague.
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Journal ArticleDOI
HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients.
Miroslav Svoboda,Jana Slyskova,Michaela Schneiderova,Peter J. Makovicky,Ludovit Bielik,Miroslav Levy,Ludmila Lipska,Beáta Hemmelová,Zdenek Kala,Markéta Protivánková,Ondrej Vycital,Vaclav Liska,Lucie Schwarzova,Ludmila Vodickova,Pavel Vodicka +14 more
TL;DR: Analysis of HOTAIR expression levels in tumor and blood of incident sporadic CRC patients in relation to their overall survival and mortality suggests that HOTA IR blood levels may serve as potential surrogate prognostic marker in sporadic CRC.
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Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects.
Pavel Vodicka,Rudolf Stetina,Veronika Polakova,Elena Tulupova,Alessio Naccarati,Ludmila Vodickova,Rajesh Kumar,Rajesh Kumar,Monika Hanova,Barbara Pardini,Barbara Pardini,Jana Slyskova,Ludovit Musak,Giuseppe De Palma,Pavel Soucek,Kari Hemminki,Kari Hemminki +16 more
TL;DR: XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms seem to exert the predominant modulating effect on irradiation-specific DNA repair capacity and the capacity to repair DNA oxidative damage, respectively.
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Comet assay to measure DNA repair: approach and applications
TL;DR: This in vitro DNA repair assay has been modified for use in animal tissues, specifically to study the effects of aging and nutritional intervention on repair, and was applied to different strains of Drosophila melanogaster proficient and deficient in DNA repair.
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DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic.
Barbara Pardini,Alessio Naccarati,Jan Novotny,Zdenek Smerhovsky,Ludmila Vodickova,Veronika Polakova,Monika Hanova,Jana Slyskova,Elena Tulupova,Rajesh Kumar,M. Bortlik,Roberto Barale,Kari Hemminki,Pavel Vodicka +13 more
TL;DR: Considering the subtle effect of the DNA repair polymorphisms on the risk of colorectal cancer, exploration of gene-gene and gene-environmental interactions with a large sample size with sufficient statistical power are recommended.
Journal ArticleDOI
Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas.
Jana Slyskova,Vlasta Korenkova,Andrew Collins,Pavel Prochazka,Ludmila Vodickova,Jiri Svec,Ludmila Lipska,Miroslav Levy,Michaela Schneiderova,Vaclav Liska,Lubos Holubec,Rajesh Kumar,Pavel Soucek,Alessio Naccarati,Pavel Vodicka +14 more
TL;DR: The feasibility of DRC evaluation in human solid tissues is shown, representing a complex marker of multigene DNA repair processes, and it is shown that tumor cells are not deficient in BER and NER, but rather follow patterns characteristic for each individual and are comparable with adjacent tissue.