D
David J. Hughes
Researcher at University College Dublin
Publications - 120
Citations - 4960
David J. Hughes is an academic researcher from University College Dublin. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 30, co-authored 108 publications receiving 4159 citations. Previous affiliations of David J. Hughes include Trinity College, Dublin & Tallaght Hospital.
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Journal ArticleDOI
A common coding variant in CASP8 is associated with breast cancer risk
Angela Cox,Alison M. Dunning,Montserrat Garcia-Closas,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Karen A. Pooley,Serena Scollen,Caroline Baynes,Bruce A.J. Ponder,Stephen J. Chanock,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Melissa C. Southey,John L. Hopper,Margaret R. E. McCredie,Graham G. Giles,Olivia Fletcher,Nichola Johnson,Isabel dos Santos Silva,Lorna Gibson,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Diana Torres,Ute Hamann,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Jenny Chang-Claude,Silke Kropp,Angela Risch,Shan Wang-Gohrke,Peter Schürmann,Natalia Bogdanova,Thilo Dörk,Rainer Fagerholm,Kirsimari Aaltonen,Carl Blomqvist,Heli Nevanlinna,Sheila Seal,Anthony Renwick,Michael R. Stratton,Nazneen Rahman,Suleeporn Sangrajrang,David J. Hughes,Fabrice Odefrey,Paul Brennan,Amanda B. Spurdle,Georgia Chenevix-Trench,Jonathan Beesley,Arto Mannermaa,Jaana M. Hartikainen,Vesa Kataja,Veli-Matti Kosma,Fergus J. Couch,Janet E. Olson,Ellen L. Goode,Annegien Broeks,Marjanka K. Schmidt,Frans B. L. Hogervorst,Laura J. van't Veer,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Sei Hyun Ahn,Sara Wedrén,Per Hall,Yen-Ling Low,Jianjun Liu,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,Alice J. Sigurdson,Alice J. Sigurdson,Denise L. Stredrick,Denise L. Stredrick,Bruce H. Alexander,Bruce H. Alexander,Jeffery P. Struewing,Jeffery P. Struewing,Paul D.P. Pharoah,Douglas F. Easton +84 more
TL;DR: It is demonstrated that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies, as well as the need for further studies to confirm putative genetic associations with breast cancer.
Journal ArticleDOI
Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome
Lorna Flanagan,Jasmin Schmid,Matthias P. Ebert,Pavel Soucek,Tereza Kunická,Vaclav Liska,Jan Bruha,Paul Neary,Nicki Dezeeuw,Massimo Tommasino,Mazda Jenab,Jochen H. M. Prehn,David J. Hughes +12 more
TL;DR: This is the first study examining Fusobacterium nucleatum (Fn) in the colonic tissue and stool of European CRC and CRA patients, and suggests Fn as a novel risk factor for disease progression from adenoma to cancer, possibly affecting patient survival outcomes.
Journal ArticleDOI
RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies
Antonis C. Antoniou,Olga M. Sinilnikova,Jacques Simard,Mélanie Léoné,Martine Dumont,Susan L. Neuhausen,Jeffery P. Struewing,Dominique Stoppa-Lyonnet,Laure Barjhoux,David J. Hughes,Isabelle Coupier,Muriel Belotti,Christine Lasset,Valérie Bonadona,Yves-Jean Bignon,Timothy R. Rebbeck,Theresa Wagner,Henry T. Lynch,Susan M. Domchek,Katherine L. Nathanson,Judy Garber,Jeffrey N. Weitzel,Steven A. Narod,Gail E. Tomlinson,Olufunmilayo I. Olopade,Andrew K. Godwin,Claudine Isaacs,Anna Jakubowska,Jan Lubinski,Jacek Gronwald,Bohdan Górski,Tomasz Byrski,Tomasz Huzarski,Susan Peock,Margaret Cook,Caroline Baynes,Alexandra Murray,Mark T. Rogers,Peter A. Daly,Huw Dorkins,Rita K. Schmutzler,Beatrix Versmold,Christoph Engel,Alfons Meindl,Norbert Arnold,Dieter Niederacher,Helmut Deissler,Amanda B. Spurdle,Xiaoqing Chen,Nicola Waddell,Nicole Cloonan,Tomas Kirchhoff,Kenneth Offit,Eitan Friedman,Bella Kaufmann,Yael Laitman,Gilli Galore,Gad Rennert,Flavio Lejbkowicz,Leon Raskin,Irene L. Andrulis,Eduard Ilyushik,Hilmi Ozcelik,Peter Devilee,Maaike P.G. Vreeswijk,Mark H. Greene,Sheila A. Prindiville,Ana Osorio,Javier Benitez,Michal Zikan,Csilla Szabo,Outi Kilpivaara,Heli Nevanlinna,Ute Hamann,Francine Durocher,Adalgeir Arason,Fergus J. Couch,Douglas F. Easton,Georgia Chenevix-Trench +78 more
TL;DR: RAD51 is the first gene to be reliably identified as a modifier of risk among BRCA1/2 mutation carriers and it is determined that the 135G-->C variant affects RAD51 splicing within the 5' UTR.
Journal Article
CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts
H.T. Claude Chan,David J. Hughes,Ruth R. French,Alison L. Tutt,Claire A. Walshe,Jessica L. Teeling,Martin J. Glennie,Mark S. Cragg +7 more
TL;DR: It was shown that phosphatidylserine translocation and mitochondrial permeability transition evoked during CD20-induced apoptosis appeared caspase independent, implying that CD20 can evoke apoptosis without the involvement of mitochondria and caspases and irrespective of redistribution into TX-100 insoluble membrane rafts.
Journal ArticleDOI
Brief report: fulminating fat embolism syndrome caused by paradoxical embolism through a patent foramen ovale.
Alastair C H Pell,David J. Hughes,John G. Keating,James Christie,Anthony Busuttil,George R. Sutherland +5 more
TL;DR: A patient undergoing treatment of a femoral fracture in whom massive fat embolism was demonstrated by transesophageal echocardiography is described, precipitating paradoxical fat emblism across a patent foramen ovale, with the subsequent development of the Fat Embolism syndrome.