Vadim I. Agol

TL;DR: Encephalomyocarditis virus (EMCV) and hepatitis C virus epitomize distinct mechanisms of internal ribosomal entry site (IRES)-mediated initiation, and initiation on some EMCV-like IRESs requires additional noncanonical initiation factors, which alter IRES conformation and promote binding of eIF4A/4G.

TL;DR: The results suggest that La protein is involved in poliovirus internal initiation of translation and might function through a similar mechanism in the translation of cellular mRNAs.

TL;DR: The data indicate that PTB and ITAF act as RNA chaperones that control the functional state of a particular IRES and that their cell-specific distribution may constitute a basis for cell- specific translational control of certain mRNAs.

TL;DR: It is shown that efficient function of this element involves two appropriately spaced smaller elements: UUUCC and an AUG, which is similar to the prokaryotic translation initiation mechanism, but in the picornavirus system the position of the UUU CC must be strictly fixed relative to upstream cis-acting elements, and the AUG may not necessarily serve as an initiation codon.

TL;DR: No major changes in the conformation of the Sabin vaccine poliovirus type 3 5'-UTR due to the transition in position 472 were observed, and the biological relevance of the conserved primary and secondary structure elements in the picornaviral5'-UTRs is discussed.