J
Jack D. Keene
Researcher at Duke University
Publications - 185
Citations - 19530
Jack D. Keene is an academic researcher from Duke University. The author has contributed to research in topics: RNA & RNA-binding protein. The author has an hindex of 69, co-authored 184 publications receiving 18795 citations. Previous affiliations of Jack D. Keene include Laboratory of Molecular Biology & Hoffmann-La Roche.
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Journal ArticleDOI
RNA regulons: coordination of post-transcriptional events
TL;DR: Several recently discovered examples of RNA operons in budding yeast, fruitfly and mammalian cells are described and their potential importance in processes such as immune response, oxidative metabolism, stress response, circadian rhythms and disease are described.
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Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome
Victoria Brown,Victoria Brown,Peng Jin,Peng Jin,Stephanie Ceman,Stephanie Ceman,Jennifer C. Darnell,William T. O'Donnell,William T. O'Donnell,Scott A. Tenenbaum,Xiaokui Jin,Yue Feng,Keith D. Wilkinson,Jack D. Keene,Robert B. Darnell,Stephen T. Warren,Stephen T. Warren +16 more
TL;DR: It is concluded that translational dysregulation of mRNAs normally associated with FMRP may be the proximal cause of fragile X syndrome, and candidate genes relevant to this phenotype are identified.
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RNA recognition: towards identifying determinants of specificity.
TL;DR: Structural analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.
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Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability
Neelanjan Mukherjee,David L. Corcoran,Jeffrey Nusbaum,Jeffrey Nusbaum,David W. Reid,Stoyan Georgiev,Markus Hafner,Markus Hafner,Manuel Ascano,Manuel Ascano,Thomas Tuschl,Thomas Tuschl,Uwe Ohler,Jack D. Keene +13 more
TL;DR: Comparison of the spatial patterns surrounding HuR and miRNA binding sites provided functional evidence for HuR-dependent antagonism of proximal miRNA-mediated repression and it is concluded that HuR coordinates gene expression outcomes at multiple interconnected steps of RNA processing.
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RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts
TL;DR: RNP immunoprecipitation–microarray (RIP-Chip) allows the identification of discrete subsets of RNAs associated with multi-targeted RNA-binding proteins and provides information regarding changes in the intracellular composition of mRNPs in response to physical, chemical or developmental inducements of living systems.