V
Valentin Jaumouillé
Researcher at National Institutes of Health
Publications - 26
Citations - 2098
Valentin Jaumouillé is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Actin cytoskeleton & Cytoskeleton. The author has an hindex of 16, co-authored 21 publications receiving 1692 citations. Previous affiliations of Valentin Jaumouillé include French Institute of Health and Medical Research & Pasteur Institute.
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Journal ArticleDOI
The Cell Biology of Phagocytosis
TL;DR: Current knowledge of the cellular and molecular basis of phagosome formation and maturation is summarized and the manner in which phagocytosis is subverted by certain pathogens is discussed.
Journal ArticleDOI
The position of lysosomes within the cell determines their luminal pH
TL;DR: Analysis of luminal lysosomal pH in combination with heterologous expression of lysOSomal-associated proteins indicates that peripheralLysosomes are more alkaline than juxtanuclear ones and that depletion of Rab7 and its effector, RILP, are associated with and can account for the reduced acidification.
Journal ArticleDOI
Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering.
Valentin Jaumouillé,Yoav Farkash,Khuloud Jaqaman,Raibatak Das,Clifford A. Lowell,Sergio Grinstein +5 more
TL;DR: Stimulation of Src-family and Syk kinases during phagocytosis induces reorganization of the cytoskeleton both locally and distally in a manner that alters receptor mobility and clustering, generating a feedback loop that facilitates engagement of FcγR at the tip of pseudopods, directing the progression of phagocytetosis.
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Coupling of β 2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis
TL;DR: Macrophages use tyrosine kinase signalling to build a mechanosensitive, talin- and vinculin-mediated, focal adhesion-like molecular clutch, which couples integrins to cytoskeletal forces to drive particle engulfment.
Journal ArticleDOI
Crl activates transcription initiation of RpoS-regulated genes involved in the multicellular behavior of Salmonella enterica serovar Typhimurium.
Véronique Robbe-Saule,Valentin Jaumouillé,Marie-Christine Prévost,Stéphanie Guadagnini,Christelle Talhouarne,Hayette Mathout,Annie Kolb,Françoise Norel +7 more
TL;DR: It is shown that the Crl protein of Salmonella serovar Typhimurium is required for development of a typical rdar morphotype and for maximal expression of the csgD, csgB, adrA, and bcsA genes, which are involved in curli and cellulose biosynthesis, which suggests that Crl has a major physiological impact at low concentrations of sigma(S).