V
Valentina Di Gialleonardo
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 18
Citations - 889
Valentina Di Gialleonardo is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: In vivo & Biodistribution. The author has an hindex of 11, co-authored 18 publications receiving 741 citations. Previous affiliations of Valentina Di Gialleonardo include University Medical Center Groningen & Sapienza University of Rome.
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Journal ArticleDOI
ATM-ATR–dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
Alessandra Soriani,Alessandra Zingoni,Cristina Cerboni,Maria Luisa Iannitto,Maria Rosaria Ricciardi,Valentina Di Gialleonardo,Marco Cippitelli,Cinzia Fionda,Maria Teresa Petrucci,Anna Guarini,Robin Foà,Angela Santoni +11 more
TL;DR: It is shown that myeloma cells treated with low doses of therapeutic agents commonly used in the management of patients with MM, such as doxorubicin, melphalan, and bortezomib, up-regulate DNAM-1 and NKG2D ligands and suggest that NK cells represent an immunosurveillance mechanism toward cells undergoing stress-induced senescent programs.
Journal ArticleDOI
N-(4-18F-Fluorobenzoyl)Interleukin-2 for PET of Human-Activated T Lymphocytes
Valentina Di Gialleonardo,Alberto Signore,Andor W. J. M. Glaudemans,Rudi Dierckx,Erik F. J. de Vries +4 more
TL;DR: 18F-FB-IL2 is stable, is biologically active, and allows in vivo detection of activated T lymphocytes, and capable of stimulating T cells to an extent similar to native IL2.
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In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors.
Lucia Salamanca-Cardona,Hardik Shah,Alex J. Poot,Fabian Correa,Valentina Di Gialleonardo,Hui Lui,Vesselin Z. Miloushev,Kristin L. Granlund,Sui S. Tee,Justin R. Cross,Craig B. Thompson,Kayvan R. Keshari,Kayvan R. Keshari +12 more
TL;DR: It is demonstrated that in vivo HP [1-13C] glutamine can be used to non-invasively measure glutamine-derived HP 2-HG production, and that, in a context-dependent manner, glutamines can be a primary carbon source for 2- HG production in mutant IDH tumors.
Journal ArticleDOI
Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models
Brandon Carney,Brandon Carney,Giuseppe Carlucci,Beatriz Salinas,Valentina Di Gialleonardo,Susanne Kossatz,Axel Vansteene,Valerie A. Longo,Alexander Bolaender,Gabriela Chiosis,Kayvan R. Keshari,Kayvan R. Keshari,Wolfgang A. Weber,Wolfgang A. Weber,Thomas Reiner,Thomas Reiner +15 more
TL;DR: ParPi is a selective PARP1 imaging agent that can be used to visualize glioblastoma in xenograft and orthotopic mouse models with high precision and good signal/noise ratios and offers new opportunities to non-invasively image tumor growth and monitor interventions.
Journal ArticleDOI
Imaging of β-Cell Mass and Insulitis in Insulin-Dependent (Type 1) Diabetes Mellitus
Valentina Di Gialleonardo,Erik F. J. de Vries,Marco Di Girolamo,Ana Maria Quintero,Rudi Dierckx,Alberto Signore +5 more
TL;DR: The availability of a noninvasively quantify β-cell mass in vivo could be useful for understanding the natural history of human insulin-dependent (type 1) diabetes mellitus, to early diagnose children at risk to develop overt diabetes, and to select patients to be treated with immunotherapies aimed at blocking the insulitis.