Valeria Tosello

TL;DR: The data suggest that a division of labor between CM and EM Tregs ensures tolerance at lymphoid and peripheral locations including tumor sites, and is the main Treg subset found in ovarian tumors.

TL;DR: It is demonstrated that CXCL12 expression may be associated with EBV infection and suggested that the CXCR4/CXCL 12 axis may participate in the EBV-associated lymphomagenesis process in immunodeficient hosts and demonstrated that antagonizing the CxCL12/CxCR4 axis in vivo strongly counteracted lymphoma development.

TL;DR: It is shown that hypoxia is associated with up-regulation of CXCR4 expression in human normal and malignant B cells, through both transcriptional and posttranslational mechanisms.

TL;DR: In a Cold Target Inhibition assay, lytic activity of a mixed leukocyte-tumor culture was inhibited in an overlapping fashion by both the TS/A line used for restimulation and 293L(d) cells loaded with gp70(423-431) peptide, thus demonstrating that all or most of the cytotoxic activity was directed exclusively against this antigenic epitope.

TL;DR: Compared the TCR usage of Melan-A-specific T cells from different compartments of a single melanoma patient to evaluate possible clonotype expansion or preferential homing over a 4-mo follow-up period buttress the notion that the CTLs recognizing the immunodominant Ag of Mela-A comprise a high number of different clonotypic TCR.