Antonio Rosato

TL;DR: It is shown that the activity of TAZ, a transducer of the Hippo pathway, is required to sustain self-renewal and tumor-initiation capacities in breast CSCs and reveals a mechanistic basis of the control of Hippo kinases by cell polarity.

TL;DR: This work highlights a new layer of signalling integration, feeding on YAP/TAZ function at the chromatin level, which occurs almost exclusively from distal enhancers that contact target promoters through chromatin looping.

TL;DR: Two common oncogenic lesions, mutant-p53 and Ras, selected in early neoplasms to promote growth and survival, also prefigure a cellular set-up with particular metastasis proclivity by TGFbeta-dependent inhibition of p63 function.

TL;DR: These findings suggest a new pathway by which Dicer inhibition drifts epithelial cancer toward a less-differentiated, mesenchymal fate to foster metastasis, and attenuates miRNA biosynthesis by targeting Dicer, a key component of the miRNA processing machinery.

TL;DR: It is shown that YAP/TAZ activity is controlled by the SREBP/mevalonate pathway, which is required for proliferation and self-renewal of breast cancer cells and reveals an additional layer of YAP-TAZ regulation by metabolic cues.