V
Valerio Chiurchiù
Researcher at Università Campus Bio-Medico
Publications - 59
Citations - 3097
Valerio Chiurchiù is an academic researcher from Università Campus Bio-Medico. The author has contributed to research in topics: Inflammation & Cannabinoid receptor. The author has an hindex of 26, co-authored 49 publications receiving 2242 citations. Previous affiliations of Valerio Chiurchiù include University of Rome Tor Vergata & University of Teramo.
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Journal ArticleDOI
Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
TL;DR: This review summarizes current knowledge on the involvement of the main classes of endogenous bioactive lipids—namely classical eicosanoids, pro-resolving lipid mediators, lysoglycerophospholipid/sphingolipids, and endocannabinoids—in the cellular and molecular mechanisms that lead to the pathogenesis of chronic disorders.
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Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses
Valerio Chiurchiù,Alessandro Leuti,Jesmond Dalli,Anders Jacobsson,Luca Battistini,Mauro Maccarrone,Charles N. Serhan +6 more
TL;DR: D-series resolvins and maresin 1 modulate adaptive immune responses in human peripheral blood lymphocytes and reduce cytokine production by activated CD8+ T cells and CD4+ T helper 1 (TH1) and TH17 cells but do not modulate T cell inhibitory receptors or abrogate their capacity to proliferate.
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Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
Ismael Galve-Roperh,Valerio Chiurchiù,Javier Díaz-Alonso,Monica Bari,Manuel Guzmán,Mauro Maccarrone +5 more
TL;DR: Endocannabinoid (eCB) signaling has been shown to regulate proliferation and differentiation of mesoderm-derived hematopoietic and mesenchymal stem cells, with a key role in determining the formation of several cell types in peripheral tissues, including blood cells, adipocytes, osteoblasts/osteoclasts and epithelial cells.
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Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors.
Maria Teresa Cencioni,Valerio Chiurchiù,Giuseppina Catanzaro,Giovanna Borsellino,Giorgio Bernardi,Luca Battistini,Mauro Maccarrone +6 more
TL;DR: The effects of the endocannabinoid AEA on primary human T-lymphocytes are investigated for the first time, demonstrating that it is a powerful modulator of immune cell functions and clarified that CB2R mediates the immunosuppressive activity of AEA.
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TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice
Maria Cristina Marrone,Annunziato Morabito,Michela Giustizieri,Valerio Chiurchiù,Alessandro Leuti,Marzia Mattioli,Sara Marinelli,Loredana Riganti,Marta Lombardi,Emanuele Murana,Antonio Totaro,Daniele Piomelli,Davide Ragozzino,Sergio Oddi,Mauro Maccarrone,Claudia Verderio,Silvia Marinelli +16 more
TL;DR: Findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas.