D
Daniele Piomelli
Researcher at University of California, Irvine
Publications - 528
Citations - 52717
Daniele Piomelli is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Endocannabinoid system & Anandamide. The author has an hindex of 104, co-authored 505 publications receiving 49009 citations. Previous affiliations of Daniele Piomelli include Heidelberg University & University of Connecticut.
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Journal ArticleDOI
The molecular logic of endocannabinoid signalling
TL;DR: The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis).
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Formation and inactivation of endogenous cannabinoid anandamide in central neurons.
V. Di Marzo,Angelo Fontana,Hugues Cadas,S. Schinelli,Guido Cimino,J.-C. Schwartz,Daniele Piomelli +6 more
TL;DR: It is reported that anandamide is produced in and released from cultured brain neurons in a calcium ion-dependent manner when the neurons are stimulated with membrane-depolarizing agents, indicating that multiple biochemical pathways may participate in an andamide formation in brain tissue.
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Role of Endogenous Cannabinoids in Synaptic Signaling
TL;DR: The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.
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Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
Marja D. Van Sickle,Marnie Duncan,Philip J. Kingsley,Abdeslam Mouihate,Paolo Urbani,Ken Mackie,Nephi Stella,Alexandros Makriyannis,Daniele Piomelli,Joseph S. Davison,Lawrence J. Marnett,Vincenzo Di Marzo,Quentin J. Pittman,Kamala D. Patel,Keith A. Sharkey +14 more
TL;DR: These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.
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A second endogenous cannabinoid that modulates long-term potentiation
TL;DR: 2-AG activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses, indicating that 2-AG is a second endogenous cannabinoid ligand in the central nervous system.