Showing papers by "Valery M. Dembitsky published in 2007"
TL;DR: Research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species, confirmed to show antimicrobial, antibacterial, anticancer, and other activities are described.
Abstract: The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species. More than 210 compounds have been confirmed to show antimicrobial, antibacterial, anticancer, and other activities. Structures, origins, biosynthesis, photodimerization, and biological activities of a selection of cyclobutane-containing alkaloids and selected synthethic analogs of natural alkaloids are reviewed.
258 citations
TL;DR: The role of natural and synthetic allenic and cumulenic lipids and other related compounds as an important source of leads for drug discovery is emphasized.
164 citations
TL;DR: The role of terrestrial and marine peroxides as an important source of leads for drug discovery is emphasized, with computer program PASS some additional biological activities are predicted, which point toward new possible applications of these compounds.
Abstract: Present review describes research on novel natural anticancer agents isolated from terrestrial and marine sources. More than 120 cytotoxic anticancer compounds have shown confirmed activity in vitro tumor cell lines bioassay and are of current interest to Natural Cancer Institute for further in vivo evaluation. Intensive searches for new classes of pharmacologically potent agents produced by terrestrial and marine organisms have resulted in the discovery of dozens of compounds possessing high cytotoxic activities. However, only a limited number of them have been tested in pre-clinical and clinical trials. One of the reasons is a limited supply of the active ingredients from the natural sources. However, the pre-clinical and clinical development of many terrestrial and/or marine-derived natural products into pharmaceuticals is often hampered by a limited supply from the natural source. Total synthesis is of vital importance in these situations, allowing for the production of useful quantities of the target compound for further biological evaluation. With computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of terrestrial and marine peroxides as an important source of leads for drug discovery.
106 citations
TL;DR: Low molecular, hydroxy, dioic, saturated and unsaturated fatty acids were determined of six cyanobacterial species belonging to genus Nostoc and in different habitats: freshwater, terrestrial, and as well as symbionts.
62 citations
TL;DR: In this article, three unifloral Palestinian honey samples that originate from Thymus capitatus, Thymelaea hirsuta, and Tolpis virgata were analyzed by using Headspace-Solid Phase Microextraction Gas Chromatography-Mass Spectrometry (HS-SPME-GC-MS).
59 citations
TL;DR: HS and SD-GC-MS have proved that most of the cultivated thyme samples examined has thymol isomer as the major phenolic constituent.
Abstract: Background: A comparative analysis by using static headspace (HS) and steam distillation (SD) GC-MS of the volatile and the semi-volatile secondary metabolites from leaves of cultivated Majorana syriaca. Methods: The essential oils endogenous to cultivated thyme were isolated and identifi ed by HS-GC-MS technology and compared to those from SD-GC-MS. Results: The HS-GC-MS results showed that the Palestinian cultivated thyme is rich in monoterpene hydrocarbons and phenolic monoterpenes such as α-phellandrene, α-pinene, β-myrcene, m-cymene, p-cymene, γ-terpinene, thymol and carvacrol. In all the samples γ-terpinene, p-cymene, thymol and carvacrol were the most abundant compounds. Conclusions: HS and SD-GC-MS have proved that most of the cultivated thyme samples examined has thymol isomer as the major phenolic constituent.
19 citations
TL;DR: Frankincense and olibanum were chemically analyzed to determine compounds that would enable the differentiation of the two products and three new compounds were identified, which may be either naturally occuring or pyrolytic products.
Abstract: Frankincense (Boswellia carterii) and olibanum (B. serrata) were chemically analyzed to determine compounds that would enable the differentiation of the two products. Typical compounds for both spe...
7 citations
Journal Article•
TL;DR: The presence of sulfolipids in algae, diatoms, and marine invertebrates has been reported in several review articles and they have been identified in more than 30 species of green, brown, and red freshwater and marine macrophytic algae.
Abstract: Sulfolipids were originally discovered in diatom species, in 1966, by Morris Kates [1–3]. High levels of these sulfolipids have been found in the alga Ochromonas danica (Chrysophyceae, Chrysophyta) where they constitute 15% of total lipids and 3% of the dry weight of heterotrophically grown, stationary-phase cells [4,5]. More recently, sulfolipids have also been identified in more than 30 species of green (Chlorophyceae), brown (Phaeophyceae), and red (Rhodophyceae) freshwater and marine macrophytic algae [6–8] and other microalgal species [9–14]. The presence of sulfolipids in algae, diatoms, and marine invertebrates has been reported in several review articles [15–20].
7 citations
TL;DR: In this article, the occurrence of saturated (14:0, 15,0, 16:0 and 18:0), unsaturated (7−16:1, 7−18):1, 9−18:2, 9,12,15-18:3) acids, together with novel cyclic sulfur-containing fatty acids in garlic (Allium sativum) was reported.
Abstract: The occurrence of saturated (14:0, 15:0, 16:0, and 18:0), and unsaturated (7–16:1, 7–18:1, 9–18:1, 9,12–18:2, 9,12,15–18:3) acids, together with novel cyclic sulfur-containing fatty acids in garlic (Allium sativum) is reported. Organosulfur compounds, fatty acids, and sulfur-containing fatty acids were separated and characterized by GC–MS with serially coupled capillary columns with consecutive nonpolar and semipolar stationary phases.
6 citations
TL;DR: In this article, 2-Propargyl-1,3-dicarbonyl derivatives, namely the corresponding cumulenes and diethoxyphosphoryloxy containing substances in the reactions with primary amines, are converted into the corresponding 1,2,3,5-tetrasubstituted pyrroles.
Abstract: 2-Propargyl-1,3-dicarbonyl derivatives, namely the corresponding cumulenes and diethoxyphosphoryloxy containing substances in the reactions with primary amines, are converted into the corresponding 1,2,3,5-tetrasubstituted pyrroles. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:220–225, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20265
6 citations
TL;DR: In this article, 2-Propargyl-1,3-dicarbonyl derivatives, namely the corresponding cumulenes and diethoxyphosphoryloxy containing substances in the reactions with primary amines, are converted into the corresponding 1,2,3,5-tetrasubstituted pyrroles.
Abstract: 2-Propargyl-1,3-dicarbonyl derivatives, namely the corresponding cumulenes and diethoxyphosphoryloxy containing substances in the reactions with primary amines, are converted into the corresponding 1,2,3,5-tetrasubstituted pyrroles. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:220–225, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20265