Vanessa Valdiglesias

TL;DR: Because of its sensitivity, efficiency and mechanistic relevance, the γH2AX assay has great potential as a DNA damage biomarker; however, the technical and epidemiological heterogeneity highlighted in this review infer a necessity for experimental standardization of the assay.

TL;DR: The quality of data from a random selection of studies is examined, from an epidemiological and statistical point of view, in order to establish baseline parameters of DNA damage and to investigate associations between comet assay measurements and factors such as sex, age, smoking status, nutrition, lifestyle, etc.

TL;DR: Despite further investigations are required to elucidate OA mechanisms of action, toxicokinetics, and harmful effects, there are enough evidences illustrating its toxicity, not related to DSP induction, supporting a revision of the current regulation on OA levels in food.

TL;DR: The results obtained in this work contribute to increase the knowledge on the genotoxic and cytotoxic potential of ZnO NPs in general, and specifically on human neuronal cells, but further investigations are required to understand the action mechanism underlying the cytot Toxic and Genotoxic effects observed.

TL;DR: Results from these studies provide a better knowledge on the selenium activity and help to elucidate the reasons underlying its duality in order to regulate its correct use in nutrition and clinic.