V
Vanina Popova
Researcher at Janssen Pharmaceutica
Publications - 20
Citations - 463
Vanina Popova is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Treatment-resistant depression & Medicine. The author has an hindex of 5, co-authored 13 publications receiving 229 citations. Previous affiliations of Vanina Popova include Johnson & Johnson.
Papers
More filters
Journal ArticleDOI
Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study
Vanina Popova,Ella Daly,Madhukar H. Trivedi,Kimberly L. Cooper,Rosanne Lane,Pilar Lim,Christine Mazzucco,David Hough,Michael E. Thase,Richard C. Shelton,Patricio Molero,Eduard Vieta,Malek Bajbouj,Husseini K. Manji,Wayne C. Drevets,Jaskaran Singh +15 more
TL;DR: Esketamine is expected to address an unmet medical need in this population through its novel mechanism of action and rapid onset of antidepressant efficacy and is supported by the efficacy and safety of esketamine nasal spray as a rapidly acting antidepressant for patients with treatment-resistant depression.
Journal ArticleDOI
Meaningful Change in Depression Symptoms Assessed with the Patient Health Questionnaire (PHQ-9) and Montgomery-Åsberg Depression Rating Scale (MADRS) Among Patients with Treatment Resistant Depression in Two, Randomized, Double-blind, Active-controlled Trials of Esketamine Nasal Spray Combined With a New Oral Antidepressant.
Stacie Hudgens,Lysbeth Floden,Michael Blackowicz,Carol Jamieson,Vanina Popova,Maggie Fedgchin,Wayne C. Drevets,Kimberly Cooper,Rosanne Lane,Jaskaran Singh +9 more
TL;DR: Individual-level meaningful change for the PHQ-9 and MADRS was effectively quantified using a clinical anchor to interpret efficacy from patients with TRD and their treating clinicians.
Journal ArticleDOI
Approval of esketamine for treatment-resistant depression
Jaskaran Singh,Ella Daly,Maju Mathews,Maggie Fedgchin,Vanina Popova,David Hough,Wayne C. Drevets +6 more
Journal ArticleDOI
Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials.
Ziad S. Saad,Derrek P. Hibar,Maggie Fedgchin,Vanina Popova,Maura L. Furey,Jaskaran Singh,Hartmuth C. Kolb,Wayne C. Drevets,Guang Chen +8 more
TL;DR: Variation in rs1799971 (A118G) did not affect the antidepressant response to esketamine + antidepressant, andAntidepressant response to antidepressant + placebo was increased in G-allele carriers, compatible with previous reports that release of endorphins/enkephalins may play a role in mediating placebo effect.
Journal ArticleDOI
Relationship Between Dissociation and Antidepressant Effects of Esketamine Nasal Spray in Patients With Treatment-Resistant Depression
Guang Chen,Li Chen,Yun Zhang,Rosanne Lane,Pilar Lim,Ella Daly,Maura L. Furey,Maggie Fedgchin,Vanina Popova,Jaskaran Singh,Wayne C. Drevets +10 more
TL;DR: In this article , a post-hoc analysis of data from two phase 3 trials of esketamine nasal spray (ESK) in treatment-resistant depression (TRD) was performed to evaluate the relationship between dissociation and antidepressant effects of ESK.