V
Varun Gupta
Researcher at Albert Einstein College of Medicine
Publications - 20
Citations - 409
Varun Gupta is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: RNA splicing & Transcription (biology). The author has an hindex of 7, co-authored 18 publications receiving 271 citations. Previous affiliations of Varun Gupta include Yeshiva University.
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A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression
TL;DR: The decoding of histone methylarginine at key genes supports a critical role for complementary PRMT5-MEP50 transcriptional activation and repression in cancer invasion pathways and in response to TGFβ stimulation and therefore orients future chemotherapeutic opportunities.
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Ribosome-omics of the human ribosome
Varun Gupta,Jonathan R. Warner +1 more
TL;DR: It is shown that for 80%-90% of the RP genes, the molar ratio of mRNAs varies less than threefold, with little tissue specificity, and since the RPs are needed in equimolar amounts, there must be sluggish or regulated translation of the more abundant RP m RNAs and/or substantial turnover of unused RPs.
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SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing
Qing Tang,Susana Rodriguez-Santiago,Jing Wang,Jia Pu,Andrea Yuste,Varun Gupta,Alberto Moldón,Yong-Zhen Xu,Charles C. Query +8 more
TL;DR: It is shown here that hsh155 mutant alleles in Saccharomyces cerevisiae, counterparts of SF3B1 mutations frequently found in cancers, specifically change splicing of suboptimal BS pre-mRNA substrates, and this results in altered loading of the BS-U2 duplex into theSF3B complex during prespliceosome formation.
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Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production
Joshua T. Weinreb,Noura Ghazale,Kith Pradhan,Varun Gupta,Kathryn S. Potts,Brad Tricomi,Noah J. Daniels,Richard A. Padgett,Sofia de Oliveira,Amit Verma,Teresa V. Bowman +10 more
TL;DR: In this article, the DEAD-box helicase 41 (Ddx41) was identified as a gatekeeper of hematopoietic stem and progenitor cells (HSPC) production.
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MS2-TRIBE evaluates both protein-RNA interactions and nuclear organization of transcription by RNA editing
TL;DR: Repeating these results with an integrated inducible MS2 reporter indicated that MS2-TRIBE can be applied to a broad array of cells and transcripts to study spatial organization and nuclear RNA regulation.