V
Vasista Adiga
Researcher at Indian Institute of Science
Publications - 14
Citations - 252
Vasista Adiga is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Medicine & CD8. The author has an hindex of 6, co-authored 9 publications receiving 139 citations.
Papers
More filters
Journal ArticleDOI
Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis
Richa Mishra,Sakshi Kohli,Nitish Malhotra,Parijat Bandyopadhyay,Mansi Mehta,MohamedHusen Munshi,Vasista Adiga,Vijaykamal Ahuja,Radha Shandil,R. S. Rajmani,Aswin Sai Narain Seshasayee,Amit Singh +11 more
TL;DR: This work suggests the repurposing of chloroquine to potentiate and possibly shorten antibiotic treatment of tuberculosis and establishes a link between phagosomal pH, redox metabolism, and drug tolerance in replicating Mtb and suggest repositioning of CQ to shorten TB therapy and achieve a relapse-free cure.
Journal ArticleDOI
BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA– Indian adults
Srabanti Rakshit,Asma Ahmed,Vasista Adiga,Bharath K. Sundararaj,Pravat Nalini Sahoo,John Kenneth,George D'Souza,Wesley Bonam,Christina Johnson,Kees L. M. C. Franken,Tom H. M. Ottenhoff,Greg Finak,Raphael Gottardo,Kenneth Stuart,Stephen C. De Rosa,M. Juliana McElrath,M. Juliana McElrath,Annapurna Vyakarnam,Annapurna Vyakarnam +18 more
TL;DR: It is shown that BCG revaccination is immunogenic in IGRA- and IGRA+ subjects implying that Mtb pre-infection in IG RA+ subjects does not impact immunogenicity, which has implications for public health and vaccine development strategies.
Journal ArticleDOI
Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis
Srabanti Rakshit,Vasista Adiga,Soumya Nayak,Pravat Nalini Sahoo,Prabhat K. Sharma,Krista E. van Meijgaarden,J Anto Jesuraj Uk,Chirag Dhar,George D. Souza,Greg Finak,Stephen C. De Rosa,Stephen C. De Rosa,Tom H. M. Ottenhoff,Annapurna Vyakarnam,Annapurna Vyakarnam +14 more
TL;DR: A blood polyfunctional, Mtb DosR latency antigen specific, regulatory, central memory response is therefore a novel functional component of T-cell immunity in latent TB and potential correlate of protection.
Journal ArticleDOI
A century of BCG: Impact on tuberculosis control and beyond.
Asma Ahmed,Srabanti Rakshit,Vasista Adiga,Mary Dias,Pratibha Dwarkanath,George D'Souza,George D'Souza,Annapurna Vyakarnam,Annapurna Vyakarnam +8 more
TL;DR: In this article, a review of the BCG-induced immune response, its efficacy in TB control, comparison with other candidate TB vaccines and strategies to improve its efficiency including revaccination and alternate routes of administration is presented.
Journal ArticleDOI
Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity.
Shikha Yadav,Sanmoy Pathak,Mohsen Sarikhani,Shamik Majumdar,Semanti Ray,Bhagawat Chandrasekar,Vasista Adiga,Nagalingam R. Sundaresan,Dipankar Nandi +8 more
TL;DR: This study clearly highlights the NOS2-dependent and -independent responses in this mouse model of peritonitis induced sepsis, and pre-treatment of Nos2-/- mice with DETA-NO, a NO donor, upon infection, restores neutrophil recruitment, reduces bacterial numbers in the peritoneal cavity, improves liver and cardio-vascular function and enhances survival.