V
Vera Ayres Meloni
Researcher at Federal University of São Paulo
Publications - 33
Citations - 567
Vera Ayres Meloni is an academic researcher from Federal University of São Paulo. The author has contributed to research in topics: Ring chromosome & Gene. The author has an hindex of 10, co-authored 29 publications receiving 482 citations. Previous affiliations of Vera Ayres Meloni include University of São Paulo.
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Journal ArticleDOI
Prenatal exposure to misoprostol and vascular disruption defects: a case-control study.
Fernando Regla Vargas,Lavinia Schuler-Faccini,Decio Brunoni,Chong Ae Kim,Vera Ayres Meloni,Sofia Mizuho Miura Sugayama,Lilian Maria José Albano,Juan C. Llerena,José Carlos Cabral de Almeida,Alexander G. Duarte,Denise P. Cavalcanti,Eny Maria Goloni-Bertollo,A. Conte,Gideon Koren,Antonio Addis +14 more
TL;DR: The data suggest that prenatal exposure to misoprostol is associated to the occurrence of vascular disruption defects in the newborns.
Journal ArticleDOI
Mechanisms of ring chromosome formation, ring instability and clinical consequences
Roberta Santos Guilherme,Vera Ayres Meloni,Chong Ae Kim,Renata Pellegrino,Sylvia Satomi Takeno,Nancy B. Spinner,Laura K. Conlin,Denise Maria Christofolini,Leslie Domenici Kulikowski,Maria Isabel Melaragno +9 more
TL;DR: The clinical phenotype of patients with ring chromosomes may be related with different factors, including gene haploinsufficiency, gene duplications and ring instability, as observed in patients with complete r(14) and r(22).
Journal ArticleDOI
Ring chromosome instability evaluation in six patients with autosomal rings.
C P Sodré,Roberta Santos Guilherme,Vera Ayres Meloni,Decio Brunoni,Yara Juliano,Joyce Anderson Duffles Andrade,Sintia Iole Belangero,Denise Maria Christofolini,Leslie Domenici Kulikowski,Maria Isabel Melaragno +9 more
TL;DR: It is concluded that cells with ring chromosome instability can multiply and survive in vivo, and that they can influence the patient's phenotype.
Journal ArticleDOI
Patients with a Kabuki syndrome phenotype demonstrate DNA methylation abnormalities.
Nara Sobreira,Martha Brucato,Li Zhang,Christine Ladd-Acosta,Chrissie M. Ongaco,Jane Romm,Kimberly F. Doheny,Regina Célia Mingroni-Netto,Débora Romeo Bertola,Chong Ae Kim,Ana Beatriz Alvarez Perez,Maria Isabel Melaragno,David Valle,Vera Ayres Meloni,Hans T. Bjornsson,Hans T. Bjornsson +15 more
TL;DR: Target sequencing in a cohort of 27 probands with a clinical diagnosis of Kabuki syndrome provided new insights into the relationship of genotype to epigenotype and phenotype and indicate cross-talk between histone and DNA methylation machineries exposed by inborn errors of the epigenetic apparatus.
Journal ArticleDOI
X‐linked intellectual disability related genes disrupted by balanced X‐autosome translocations
Mariana Moysés-Oliveira,Roberta Santos Guilherme,Roberta Santos Guilherme,Vera Ayres Meloni,Adriana Di Battista,Claudia Berlim de Mello,Silvia Bragagnolo,Danilo Moretti-Ferreira,Nadezda Kosyakova,Thomas Liehr,Gianna Carvalheira,Maria Isabel Melaragno +11 more
TL;DR: The impact of the gene interruptions in transcription and the consequences of their functional impairment in neurodevelopment are addressed and the disruption of an X‐linked intellectual disability‐related gene in patients with balanced X‐autosome translocation is revealed.