scispace - formally typeset
J

Jane Romm

Researcher at Johns Hopkins University

Publications -  22
Citations -  5132

Jane Romm is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 17, co-authored 21 publications receiving 3657 citations. Previous affiliations of Jane Romm include Johns Hopkins University School of Medicine.

Papers
More filters
Journal ArticleDOI

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Lars G. Fritsche, +185 more
- 01 Feb 2016 - 
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI

Association analysis identifies 65 new breast cancer risk loci

Kyriaki Michailidou, +396 more
- 02 Nov 2017 - 
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Journal ArticleDOI

Genetic analyses of diverse populations improves discovery for complex traits

Genevieve L. Wojcik, +90 more
- 27 Jun 2019 - 
TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.
Journal ArticleDOI

Detecting and Estimating Contamination of Human DNA Samples in Sequencing and Array-Based Genotype Data

Goo Jun, +7 more
- 02 Nov 2012 - 
TL;DR: Through a combination of analysis of in silico and experimentally contaminated samples, it is shown that the methods described can reliably detect and estimate levels of contamination as low as 1%.
Journal ArticleDOI

Discovery of common and rare genetic risk variants for colorectal cancer

Jeroen R. Huyghe, +224 more
- 01 Jan 2019 - 
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.