Vijayakumar N. Sonar

TL;DR: The use of the indole analogues identified NADPH oxidase activity as a novel upstream activity regulating Nrf2/Keap1 signaling of GCLC, provided data supporting the hypothesis that Keap1 is a downstream effector for oxid enzyme activity, and afforded in vivo data to support the hypotheses that KeAP1 thiols can act as molecular sensors of reactive oxygen species.

TL;DR: A novel series of small molecules are identified that represent a promising tool for the treatment of recurrent tumors by ionizing radiation by exploiting the underlying biophysical events responsible for thermal sensitization.

TL;DR: Systematic structure-activity relationship studies were designed to further the development and optimization of potential clinically useful thermal sensitizing agents and the most potent analog was compound 10, which potently inhibited the growth of HT-29 cells after a 41 degrees C/2h exposure.

TL;DR: An efficient and convenient method for the synthesis of substituted coumarins via Pechmann condensation of different phenols with ethylacetoacetate in the presence of ammonium cerium(IV) nitrate as the catalyst in a solvent-free media using both conventional heating and microwave irradiation is described in this article.

TL;DR: A series of hydrazone and 3-nitrovinyl analogs of indole-3-carboxaldehydes and related compounds were synthesized and screened for antitubercular activity against Mycobacterium tuberculosis H37RV in BACTEC 12B medium using the Microplate Alamar Blue Assay (MABA).