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Vilasinee Hirunpanich

Researcher at Mahasarakham University

Publications -  9
Citations -  480

Vilasinee Hirunpanich is an academic researcher from Mahasarakham University. The author has contributed to research in topics: Docosahexaenoic acid & Bioavailability. The author has an hindex of 7, co-authored 9 publications receiving 439 citations. Previous affiliations of Vilasinee Hirunpanich include Mahidol University & Showa University.

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Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats.

TL;DR: The lines of evidence suggest that the aqueous extracts from the dried calyx of roselle possess both antioxidant effects against LDL oxidation and hypolipidemic effects in vivo, however, its mechanism(s) of action remains to be elucidated.
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Antioxidant Effects of Aqueous Extracts from Dried Calyx of Hibiscus sabdariffa LINN. (Roselle) in Vitro Using Rat Low-Density Lipoprotein (LDL)

TL;DR: It is demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu(2+)-mediated oxidation of LDL (p<0.05) in vitro, and the inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml.
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Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats.

TL;DR: DHA could be used as a BA enhancer for the drugs that are extensively metabolized by CYP3A in the gut, and this finding is the first to indicate that DHA inhibits intestinal CYP 3A both in vitro and in vivo, but not P-gp.
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Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: In vitro and in vivo studies in rats

TL;DR: This study provided the first direct evidence to show that DHA has an inhibitory effect on the intestinal pre-systemic metabolism of a CYP3A substrate and that D HA has little, if any, effect onThe P-gp activity in the gut.
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Improvement of cyclosporine A bioavailability by incorporating ethyl docosahexaenoate in the microemulsion as an oil excipient

TL;DR: It was suggested that the use of DHA-EE as an oil excipient may be promising for the development of a microemulsion formulation of CsA with an improved oral bioavailability.