V
Ville Leinonen
Researcher at University of Eastern Finland
Publications - 169
Citations - 4739
Ville Leinonen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Medicine & Cerebrospinal fluid. The author has an hindex of 31, co-authored 141 publications receiving 3746 citations. Previous affiliations of Ville Leinonen include Oulu University Hospital & University of Oulu.
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Journal ArticleDOI
The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Camilla A. Hansson Petersen,Nyosha Alikhani,Homira Behbahani,Birgitta Wiehager,Pavel F. Pavlov,Irina Alafuzoff,Ville Leinonen,Akira Ito,Bengt Winblad,Elzbieta Glaser,Maria Ankarcrona +10 more
TL;DR: This work presents a unique import mechanism for Aβ in mitochondria and demonstrates both in vitro and in vivo that Aβ is located to the mitochondrial cristae, and shows that extracellulary applied Aβ can be internalized by human neuroblastoma cells and can colocalize with mitochondrial markers.
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CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings.
Toni T. Seppälä,Ossi Nerg,Anne M. Koivisto,Jaana Rummukainen,Lakshman Puli,Henrik Zetterberg,Okko T. Pyykkö,Seppo Helisalmi,Irina Alafuzoff,Mikko Hiltunen,Juha E. Jääskeläinen,J. Rinne,H. Soininen,Ville Leinonen,Sanna-Kaisa Herukka +14 more
TL;DR: Amyloid plaques and hyperphosphorylated tau in cortical brain biopsies are reflected by low CSF Aβ42 and high CSF tau and p-tau levels, respectively.
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Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.
Ville Leinonen,Irina Alafuzoff,Sargo Aalto,Timo Suotunen,Sakari Savolainen,Kjell Någren,Tero Tapiola,Tuula Pirttilä,Jaakko Rinne,Juha E. Jääskeläinen,Hilkka Soininen,Juha O. Rinne +11 more
TL;DR: This study supports the use of noninvasive [11C]PiB PET in the assessment of Abeta deposition in the brain in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens.
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Back and hip extensor activities during trunk flexion/extension: Effects of low back pain and rehabilitation
TL;DR: The activity of thegluteus maximus muscle during the flexion-extension cycle was reduced in patients with chronic low back pain, and the gluteal muscles should be taken into consideration in the rehabilitation of these patients.
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Influence of comorbidities in idiopathic normal pressure hydrocephalus — research and clinical care. A report of the ISHCSF task force on comorbidities in INPH
Jan Malm,Neill R. Graff-Radford,Masatsune Ishikawa,Bo Kristensen,Ville Leinonen,Etsuro Mori,Brian Owler,Mats Tullberg,Michael A. Williams,Norman R. Relkin +9 more
TL;DR: The task force concluded that comorbidity can be an important predictor of prognosis and post-operative outcome in INPH and future INPH research should focus on the contribution of comorbridity to overall morbidity, mortality and long-term outcomes.