Vincent C. Manganiello

TL;DR: Although its function is required for Tr cell suppressor activity, Foxp3 to a large extent amplifies and fixes pre-established molecular features of Tr cells, including anergy and dependence on paracrine IL-2.

TL;DR: Pharmaceutical interest in PDEs has been reignited by the increasing understanding of the roles of individual P DEs in regulating the subcellular compartmentalization of specific cyclic nucleotide signalling pathways, by the structure-based design of novel specific inhibitors and by the development of more sophisticated strategies to target individual PDE variants.

TL;DR: This review emphasizes the PDE3 family, including structure-function information and regulation of the adipocyte PDE2, which plays a key role in the antilipolytic action of insulin, and other aspects of different PDE families will be discussed.

TL;DR: It is suggested that in human adipocytes, TNF-alpha stimulates lipolysis through activation of MEK-ERK and subsequent increase in intracellular cAMP and the increase was abrogated by PD98059.

TL;DR: Findings provide the first genetic evidence indicating that resumption of meiosis in vivo and in vitro requires PDE3A activity, which underscores inhibition of oocyte maturation as a potential strategy for contraception.