J
Jeffrey P. Rasmussen
Researcher at University of California, Los Angeles
Publications - 26
Citations - 9004
Jeffrey P. Rasmussen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Zebrafish & FOXP3. The author has an hindex of 15, co-authored 22 publications receiving 8362 citations. Previous affiliations of Jeffrey P. Rasmussen include Howard Hughes Medical Institute & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Jason D. Fontenot,Jeffrey P. Rasmussen,Luke M. Williams,James Dooley,Andrew G. Farr,Alexander Y. Rudensky +5 more
TL;DR: Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions, and it is shown that expression ofFoxp3 is highly restricted to the subset alphabeta of T cells and, irrespective of CD25 expression, correlates with suppressor activity.
Journal ArticleDOI
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Jason D. Fontenot,Jason D. Fontenot,Jeffrey P. Rasmussen,Marc A. Gavin,Alexander Y. Rudensky +4 more
TL;DR: Gene expression analysis showed that IL-2 signaling was required for maintenance of the expression of genes involved in the regulation of cell growth and metabolism, which seems to be critically required for maintaining the homeostasis and competitive fitness of Treg cells in vivo.
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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice.
TL;DR: It is suggested that self-reactive T cells are continuously suppressed by Treg cells and that when suppression is relieved, self- reactive T cells become activated and facilitate accelerated maturation of dendritic cells.
Journal ArticleDOI
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Yuri P. Rubtsov,Jeffrey P. Rasmussen,Emil Y. Chi,Jason D. Fontenot,Luca Castelli,Xin Ye,Piper M. Treuting,Lisa Siewe,Axel Roers,William R. Henderson,Werner Müller,Alexander Y. Rudensky +11 more
TL;DR: This study suggests that Treg cells utilize multiple means to limit immune responses, and these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting.
Journal ArticleDOI
Foxp3-dependent programme of regulatory T-cell differentiation
Marc A. Gavin,Jeffrey P. Rasmussen,Jason D. Fontenot,Valeria Vasta,Vincent C. Manganiello,Joseph A. Beavo,Alexander Y. Rudensky +6 more
TL;DR: Although its function is required for Tr cell suppressor activity, Foxp3 to a large extent amplifies and fixes pre-established molecular features of Tr cells, including anergy and dependence on paracrine IL-2.