P
Per Belfrage
Researcher at Lund University
Publications - 98
Citations - 7070
Per Belfrage is an academic researcher from Lund University. The author has contributed to research in topics: Adipose tissue & Hormone-sensitive lipase. The author has an hindex of 43, co-authored 98 publications receiving 6949 citations. Previous affiliations of Per Belfrage include Vanderbilt University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides
Per Belfrage,Martha Vaughan +1 more
TL;DR: Oleic acid has a partition coefficient, upper phase/lower phase, of 1.9 (22 degrees C) in the liquid-liquid partition system described herein, and can be quantitatively removed from mixtures of triglyceride and partial glycerides by means of this partition system under conditions resembling those in a lipase assay.
Journal ArticleDOI
Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3).
TL;DR: This review emphasizes the PDE3 family, including structure-function information and regulation of the adipocyte PDE2, which plays a key role in the antilipolytic action of insulin, and other aspects of different PDE families will be discussed.
Journal ArticleDOI
Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.
TL;DR: Modulation of hormone-sensitive lipase activity by phosphorylation in uitm as well as in the intact fat cell is demonstrated and indicates that this is a significant mechanism for the hormonal short term regulation of adipose tissue lipolysis.
Journal ArticleDOI
Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3.
Cecilia Holm,Todd G. Kirchgessner,Karen L. Svenson,Gudrun Fredrikson,Staffan Nilsson,Chad G. Miller,John E. Shively,C. Heinzmann,Robert S. Sparkes,T. K. Mohandas,Aldons J. Lusis,Per Belfrage,Michael C. Schotz +12 more
TL;DR: Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin.
Journal ArticleDOI
Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin
TL;DR: Control of adipose tissue lipolysis by fast-acting lipolytic hormones and by insulin is exerted through the regulation of the phosphorylation state of a single phosphoserine residue in the hormone-sensitive lipase.