scispace - formally typeset
Search or ask a question

Showing papers by "Vincent C. O. Njar published in 2001"

Journal Article•DOI•
High-Yield Synthesis of Novel Imidazoles and Triazoles from Alcohols and Phenols.

[...]

Vincent C. O. Njar
24 Apr 2001-ChemInform

8 citations

Journal Article•DOI•
Pharmacokinetic profile of 3β-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1), a potent androgen synthesis inhibitor, in mice

[...]

Ivo P. Nnane1, Vincent C. O. Njar2, A Brodie2•
Temple University1, University of Maryland, Baltimore2
01 Sep 2001-The Journal of Steroid Biochemistry and Molecular Biology
TL;DR: VN/87-1 is a novel potent steroidal inhibitor of human testicular 17-alpha-hydroxylase/C(17,20)-lyase and shows linear kinetics at doses up to 100 mg/kg and was well absorbed from the subcutaneous site compared with absorption from the gastrointestinal tract.

8 citations

Patent•
Novel C-4 substituted retinoids

[...]

Vincent C. O. Njar1, Angela Brodie1, Ivo P. Nnane1•
University of Maryland, Baltimore1
11 Jul 2001
TL;DR: In this article, C-4 substituted all-trans retinoic acid analogs are synthesized and used to treat various cancers and dermatological diseases and conditions and also have ATRA-mimetic activity.
Abstract: Novel C-4 substituted all-trans retinoic acid analogs are synthesized and used to treat various cancers and dermatological diseases and conditions. These novel C-4 substituted all-trans retinoic acid analogs inhibit all-trans retinoic acid (ATRA) 4-hydroxylase activity, thereby inhibiting the catabolism of ATRA. These novel C-4 substituted ATRA analogs also have ATRA-mimetic activity. The substitutions at C-4 comprise azole, sulfur, oxygen, nitrogen, pyridyl, acetylinic, cyclopropyl-amine, ester, oxime, cyano, oxirone and aziridine groups.

8 citations