V
Vincent Pasque
Researcher at Katholieke Universiteit Leuven
Publications - 52
Citations - 1957
Vincent Pasque is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Reprogramming & Induced pluripotent stem cell. The author has an hindex of 22, co-authored 43 publications receiving 1582 citations. Previous affiliations of Vincent Pasque include Wellcome Trust/Cancer Research UK Gurdon Institute & University of Cambridge.
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Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes
TL;DR: This is the first report showing that naturally stored actin in an oocyte nucleus helps transcriptional reprogramming in a polymerization-dependent manner, and an actin signaling protein, Toca-1, enhances Oct4 reactivation by regulating nuclear actin polymerization.
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Epiblast Stem Cell-Based System Reveals Reprogramming Synergy of Germline Factors
Astrid Gillich,Siqin Bao,Nils Grabole,Katsuhiko Hayashi,Matthew Trotter,Vincent Pasque,Erna Magnúsdóttir,M. Azim Surani +7 more
TL;DR: A Prdm14-Klf2 synergistic effect that can accelerate and enhance reversion of mouse epiblast stem cells to a naive pluripotent state, including X reactivation and DNA demethylation is shown.
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Histone variant macroH2A confers resistance to nuclear reprogramming
Vincent Pasque,Vincent Pasque,Astrid Gillich,Astrid Gillich,Nigel Garrett,Nigel Garrett,John B. Gurdon,John B. Gurdon +7 more
TL;DR: The results uncover the decreased stability of the Xi in EpiSCs, and highlight the importance of combinatorial epigenetic repression involving macroH2A in restricting transcriptional reprogramming by oocytes.
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Zebrafish Sox7 and Sox18 function together to control arterial-venous identity.
Hélène Pendeville,Marie Winandy,Isabelle Manfroid,Olivier Nivelles,Patrick Motte,Vincent Pasque,Bernard Peers,Ingrid Struman,Joseph Martial,Marianne Voz +9 more
TL;DR: The striking similarities between the phenotype of Sox7/Sox18 morphants and Gridlock mutants strongly suggest that Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression.
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Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
TL;DR: The egg and oocyte reprogramming process includes the exchange of somatic proteins for oocyte proteins, the post-translational modification of histones and the demethylation of DNA, indicating that reprograming by nuclear transfer and by cell fusion rely on deterministic processes.