V
Vindhya Nawaratne
Researcher at Monash University
Publications - 7
Citations - 445
Vindhya Nawaratne is an academic researcher from Monash University. The author has contributed to research in topics: Allosteric regulation & Muscarinic acetylcholine receptor. The author has an hindex of 3, co-authored 3 publications receiving 373 citations. Previous affiliations of Vindhya Nawaratne include Monash University, Clayton campus.
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Journal ArticleDOI
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
David M. Thal,Bingfa Sun,Dan Feng,Vindhya Nawaratne,Katie Leach,Christian C. Felder,Mark G. Bures,David A. Evans,William I. Weis,Priti Bachhawat,Tong Sun Kobilka,Patrick M. Sexton,Brian K. Kobilka,Arthur Christopoulos +13 more
TL;DR: Comparison of crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotropium, reveals differences in the orthosteric and allosteric binding sites that contribute to a role in drug selectivity at this important receptor family.
Journal ArticleDOI
New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
Vindhya Nawaratne,Katie Leach,Nur Suraya Adina Suratman,Richard E Loiacono,Christian C. Felder,Blaine N. Armbruster,Bryan L. Roth,Patrick M. Sexton,Arthur Christopoulos +8 more
TL;DR: Results provide conclusive evidence for the retention of a functional allosteric site on the M4 DREADD and highlight a role for residues Tyr113 and Ala203 in the transmission of cooperativity.
Journal ArticleDOI
Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor IDENTIFICATION OF LIGAND-SPECIFIC AND GLOBAL ACTIVATION MECHANISMS
Vindhya Nawaratne,Katherine Leach,Christian C. Felder,Patrick M. Sexton,Arthur Christopoulos +4 more
TL;DR: These results provide new insights into the existence of multiple activation switches in G protein-coupled receptors (GPCRs), some of which can be selectively exploited by allosteric agonists, whereas others represent global activation mechanisms for all classes of ligand.
Journal ArticleDOI
Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders
Skye Montoya,Jessie Bourcier,Meghan C. Thompson,Mark Noviski,May Tan,Eric T. Wang,Xiaoli Mi,Nivetha Brathaban,Carla Barrientos Risso,Daniel Tsai,Jordan Ye,Jacob Jahn,Gabriel Pardo,Lee Cabuhat,Ryan Q. Notti,Alejandro Pardo,Maurizio Affer,Stephanie L. Yung,James Luliano,Janine Powers,Daniel W. Robbins,Vindhya Nawaratne,Tulasigeri M. Totiger,Camila Pena-Velasquez,Joanna Rhodes,Andrew D. Zelenetz,Lindsey E. Roeker,Hao Lu,Adam Linley,Anthony R. Mato,Omar Abdel-Wahab,Justin Taylor +31 more
Journal ArticleDOI
Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine Receptor
Ziva Vuckovic,Jian Wang,Vi Pham,Jesse I. Mobbs,Matthew J. Belousoff,Apurba Bhattarai,Wessel A.C. Burger,Geoff V. Thompson,Mahmuda Yeasmin,Vindhya Nawaratne,Katie Leach,Emma T van der Westhuizen,Elham Khajehali,Yi Lynn Liang,Alisa Glukhova,Denise Wootten,Craig W. Lindsley,Andrew B. Tobin,Patrick M. Sexton,Radostin Danev,Celine Valant,Yinglong Miao,Arthur Christopoulos,David M. Thal +23 more