A
Andrew B. Tobin
Researcher at University of Glasgow
Publications - 163
Citations - 6987
Andrew B. Tobin is an academic researcher from University of Glasgow. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 44, co-authored 148 publications receiving 5776 citations. Previous affiliations of Andrew B. Tobin include University of Liverpool & Princeton University.
Papers
More filters
Journal ArticleDOI
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
Lev Solyakov,Jean Halbert,Jean Halbert,Mahmood M. Alam,Jean-Phillipe Semblat,Jean-Phillipe Semblat,Dominique Dorin-Semblat,Dominique Dorin-Semblat,Luc Reininger,Luc Reininger,Andrew R. Bottrill,Sharad Mistry,Abdirhaman Abdi,Abdirhaman Abdi,Clare Fennell,Zoe Holland,Claudia Demarta,Yvan Bouza,Audrey Sicard,Audrey Sicard,Marie-Paule Nivez,Sylvain C.P. Eschenlauer,Tenzing Lama,Divya Catherine Thomas,Pushkar Sharma,Shruti Agarwal,Selina Kern,Gabriele Pradel,Michele Graciotti,Andrew B. Tobin,Christian Doerig,Christian Doerig,Christian Doerig +32 more
TL;DR: This work identifies 1177 phosphorylation sites on 650 parasite proteins that are involved in a wide range of general cellular activities such as DNA synthesis, transcription and metabolism as well as key parasite processes such as invasion and cyto-adherence and defines potential anti-malarial drug targets within the parasite kinome.
Journal ArticleDOI
Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
TL;DR: Evidence is reviewed that GPCR phosphorylation is, in fact, a flexible and dynamic regulatory process in which GPCRs are phosphorylated in a unique manner that is associated with the cell type in which the receptor is expressed.
Journal ArticleDOI
The experimental power of FR900359 to study Gq-regulated biological processes
Ramona Schrage,Anna Lena Schmitz,Evelyn Gaffal,Suvi Annala,Stefan Kehraus,Daniela Wenzel,Katrin M. Büllesbach,Tobias Bald,Asuka Inoue,Asuka Inoue,Yuji Shinjo,Ségolène Galandrin,Naveen Shridhar,Michael Hesse,Manuel Grundmann,Nicole Merten,Thomas H. Charpentier,Matthew K. Martz,Adrian J. Butcher,Tanja Slodczyk,Sylvain Armando,Maike Effern,Yoon Namkung,Laura Jenkins,Velten Horn,Anne Stößel,Harald Dargatz,Daniel Tietze,Diana Imhof,Céline Galés,Christel Drewke,Christa E. Müller,Michael Hölzel,Graeme Milligan,Andrew B. Tobin,Jesus Gomeza,Henrik G. Dohlman,John Sondek,T. Kendall Harden,Michel Bouvier,Stéphane A. Laporte,Junken Aoki,Junken Aoki,Bernd K. Fleischmann,Klaus Mohr,Gabriele M. König,Thomas Tüting,Evi Kostenis +47 more
TL;DR: The plant-derived depsipeptide FR900359 is systematically characterize as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms and elaborate its molecular mechanism of action.
Journal ArticleDOI
The Pharmacology and Function of Receptors for Short-Chain Fatty Acids.
TL;DR: The physiologic roles of FFA2 and FFA3 are reviewed, the recent development and use of receptor-selective pharmacological tool compounds and genetic models available to study these receptors are presented, and evidence of the potential therapeutic value of targeting this emerging receptor pair is presented.
Journal ArticleDOI
G-protein-coupled receptor phosphorylation: where, when and by whom.
TL;DR: This review investigates the possibility that the multi‐site nature of GPCR phosphorylated reflects the importance of specific phosphorylation events which mediate distinct signalling outcomes, and may provide for a flexible regulatory mechanism that can be tailored in a tissue specific manner to regulate physiological processes.