V
Vinoth Prasanna Gunasekaran
Researcher at Bharathidasan University
Publications - 9
Citations - 120
Vinoth Prasanna Gunasekaran is an academic researcher from Bharathidasan University. The author has contributed to research in topics: Cancer & Reproductive toxicity. The author has an hindex of 6, co-authored 9 publications receiving 68 citations.
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Journal ArticleDOI
p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models
Ramakrishnan Sabitha,Kumari Nishi,Vinoth Prasanna Gunasekaran,Balupillai Agilan,Ernest David,Govindhan Annamalai,Rajamanickam Vinothkumar,Malliga Perumal,Latha Subbiah,Mathan Ganeshan +9 more
TL;DR: The ameliorative consequence of PCA on ethanol induced oxidative stress and apoptosis was achieved by suppressing the expression of CYP2E1 and overexpressing Nrf2 and its target protein HO-1 in rat liver tissue and PCA was marked to be an effective antioxidant with notable hepatoprotection.
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p-Coumaric acid ameliorates ethanol–induced kidney injury by inhibiting inflammatory cytokine production and NF–κB signaling in rats
Ramakrishnan Sabitha,Kumari Nishi,Vinoth Prasanna Gunasekaran,Govindhan Annamalai,Balupillai Agilan,Mathan Ganeshan +5 more
TL;DR: Jp-Coumaric acid is investigated as a promising candidate for ethanol-induced kidney toxicity by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.
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Protective effects of p‑coumaric acid on ethanol induced male reproductive toxicity.
Kumari Nishi,Sabitha Ramakrishnan,Vinoth Prasanna Gunasekaran,Kaushal Parkash,Arumugam Ramakrishnan,Natesan Vijayakumar,Mathan Ganeshan +6 more
TL;DR: Overall, the results showed that PCA mitigates alcohol induced male reproductive toxicity and improves reproductive health in male Wistar rats.
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Doxorubicin-induced female reproductive toxicity: an assessment of ovarian follicular apoptosis, cyclicity and reproductive tissue histology in Wistar rats.
TL;DR: The results suggest that though doxorubicin is a potential chemotherapeutic drug for many tumors, but the risk of adverse effects on the female reproductive system is there even at low doses.
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Identification of 2,4-dihydroxy-5-pyrimidinyl Imidothiocarbomate as a Novel Inhibitor to Y Box Binding protein-1 (YB-1) and Its Therapeutic Actions Against Breast Cancer
Vinoth Prasanna Gunasekaran,Kumari Nishi,Dakshinamurthy Sivakumar,Thirunavukkarasu Sivaraman,Ganeshan Mathan +4 more
TL;DR: DPI inhibited YB‐1 nuclear translocation, thereby exhibited anti‐apoptotic, anti‐proliferative and anti‐metastatic activities and increases the therapeutic potential of commercial breast cancer drug doxorubicin.