V
Violaine Moreau
Researcher at French Institute of Health and Medical Research
Publications - 57
Citations - 3501
Violaine Moreau is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Podosome & RHOA. The author has an hindex of 24, co-authored 52 publications receiving 3209 citations. Previous affiliations of Violaine Moreau include University of Bordeaux & Centre national de la recherche scientifique.
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Journal ArticleDOI
Type I collagen fibrils: an inducer of invadosomes.
Julie Di Martino,Julie Di Martino,Violaine Moreau,Violaine Moreau,Frédéric Saltel,Frédéric Saltel +5 more
TL;DR: It is determined that type I collagen fibrils are a universal and potent inducer of invadosomes in all tested cells and that the discoidin receptor 1 (DDR1) is the receptor involved in linear invadosome formation via a linear Cdc42-Tuba pathway.
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Rnd3/RhoE expression is regulated by G-actin through MKL1-SRF signaling pathway.
Léo Piquet,Terezinha Robbe,Véronique Neaud,Sara Basbous,Stéphanie Rosciglione,Frédéric Saltel,Violaine Moreau +6 more
TL;DR: It is demonstrated that this novel MKL1‐SRF target is required in mechanosensitive mechanisms such as cell spreading and spheroid formation and plays a key role in the feedback loop of the actin/MKL/SRF signaling circuit.
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Pathophysiological functions of Rnd proteins
TL;DR: Rnd proteins' involvement in physiological and pathological conditions with a focus on the neuronal and vascular systems is described, and their implications in tumorigenesis are summarized.
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Type I collagen fibrils and discoidin domain receptor 1 set invadosomes straight.
Violaine Moreau,Frédéric Saltel +1 more
TL;DR: It is demonstrated that the collagen sensor discoidin domain receptor 1 (DDR1) interacts with type I collagen fibrils to allow proteolysis-based cancer cell invasion through the formation of a new class of invadosomes, termed linear invadosome.
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Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation
Margaux Sala,Nathalie Allain,Mélanie Moreau,Arnaud Jabouille,Elodie Henriet,Aya Abou-Hammoud,Arnaud Uguen,Sylvaine Di-Tommaso,Cyril Dourthe,Anne-Aurélie Raymond,Jean-William Dupuy,E. Gérard,Nathalie Dugot-Senant,Benoit Rousseau,Jean-Philippe Merlio,Anne Pham-Ledart,Béatrice Vergier,Sophie Tartare-Deckert,Violaine Moreau,Frédéric Saltel +19 more
TL;DR: It is demonstrated that DDR2 inhibition induces a decrease in AXL expression and reduces stress fiber formation in resistant melanoma cell lines and could be a new and promising strategy for countering this resistance mechanism.