V
Virginia L. Miller
Researcher at University of North Carolina at Chapel Hill
Publications - 146
Citations - 15020
Virginia L. Miller is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Yersinia enterocolitica & Virulence. The author has an hindex of 60, co-authored 145 publications receiving 14324 citations. Previous affiliations of Virginia L. Miller include Princeton University & Harvard University.
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A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.
TL;DR: Certain environmental signals (i.e., osmolarity and the presence of amino acids) are tightly coupled to the expression of toxR-regulated proteins and therefore may be signals that are directly sensed by the ToxR protein.
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Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin
TL;DR: It is concluded that the toxR gene plays a central role in the transcriptional regulation of multiple virulence genes of V. cholerae.
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Herpesvirus latency confers symbiotic protection from bacterial infection
Erik S. Barton,Douglas W. White,Jason S. Cathelyn,Kelly A. Brett-McClellan,Michael Engle,Michael S. Diamond,Virginia L. Miller,Herbert W. Virgin +7 more
TL;DR: Whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, the data suggest that latency is a symbiotic relationship with immune benefits for the host.
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Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein
TL;DR: DNA binding assays and a deletion analysis of the cholera toxin promoter support a model for transcriptional activation that involves ToxR binding to a tandemly repeated 7 bp DNA sequence 56 bp upstream of the transcriptional start point.
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Molecular basis of the interaction of Salmonella with the intestinal mucosa.
TL;DR: Animal and in vitro cell culture models for the interaction of enterocolitis-causing salmonellae with the intestinal mucosa are reviewed, along with the bacterial genes that are thought to affect this interaction.